Exosomes with Immune Modulatory Features Are Present in Human Breast Milk1

By C. Admyre, Sara M. Johansson, K. R. Qazi, J. Filén, R. Lahesmaa, M. Norman, E. Neve, A. Scheynius, S. Gabrielsson. Journal of Immunology, 2007

1,161 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Obstetrics and Gynecology

View Paper: https://www.semanticscholar.org/paper/0995d3ad812ee19b2db6b74c76238f64ce9cda5c

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Citations in the corpus

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses (2011, background): “Exosomes displaying immunosuppressive effects on T cells are present in milk and colostrum as well (78).”
Exosomes: extracellular organelles important in intercellular communication. (2010, background): “[37] Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S.”
Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages (2011, background): “Flow cytometry was performed by capturing the exosomes on anti-MHC class II coated beads, and further stain with anti-CD9, antiCD63 or anti-CD81.”
ExoCarta 2012: database of exosomal proteins, RNA and lipids (2011, background): “Recent studies have shown that exosomes can be isolated in vivo in bodily fluids such as blood (8), urine (9), breast milk (10), amniotic fluid (11), malignant ascites (12), bronchoalveolar lavage fluid (13) and synovial fluid (14).”
Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation (2012, background): “They can be detected in body fluids including blood plasma, urine, saliva, amniotic fluid, breast milk, and pleural ascites [10–13], and contain proteins, lipids, and RNA representative of the host cell [14–18].”
Standardization of sample collection, isolation and analysis methods in extracellular vesicle research (2013, neutral): “breast milk (35,37), ascites (38,39), amniotic fluid (40,41),”
The biology, function, and biomedical applications of exosomes (2020, positive): “Breast milk– derivedexosomes containmiRNAswith immunerelated functions (50) and enhance the number of peripheral blood–derived T-regulatory cells ex vivo, possibly to regulate immune tolerance (51).”
Extracellular vesicles: Exosomes, microvesicles, and friends (2013, background): “…1985; Park et al., 2011; Aalberts et al., 2012), blood (Caby et al., 2005), urine (Pisitkun et al., 2004), saliva (Ogawa et al., 2011), breast milk (Admyre et al., 2007), amniotic fluid (Asea et al., 2008), ascites fluid (Andre et al., 2002), cerebrospinal fluid (Vella et al., 2007), and bile…”
Engineering exosomes for targeted drug delivery (2021, background): “Exosomes are now widely found in all bodily fluids and tissues, including blood [6], urine [7], breast milk [8], amniotic/synovial/ascites fluid [9], saliva [10], and adipose tissue [11].”
Bovine milk-derived exosomes for drug delivery (2015, background): “Reports have also indicated presence of the RNA moieties in the exosomes isolated from milk [12, 45, 46].”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “It has been established that breast milk EVs differ from DC EVs, and it has been suggested that they may originate from other cells present in breast milk, from epithelial breast cells or even from other compartments of the body that can reach breast milk through the blood circulation (308).”
Using exosomes, naturally-equipped nanocarriers, for drug delivery (2015, background): “in human breast milk can boost the immune response and alter the T cell balance toward a regulatory phenotype [65,66].”
Exosomes and their roles in immune regulation and cancer. (2015, background): “[122] showed that exosome-like vesicles epressed IL-2 and IFN- production in PBMCs.”