Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery.

By Benjamin D. Towbin, Cristina González-Aguilera, R. Sack, Dimos Gaidatzis, V. Kalck, P. Meister, P. Askjaer, S. Gasser. Cell, 2012

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Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data (2013, background): “Second, the unknotted conformation of the fractal globules (which is not a feature of equilibrium globules) allows easy opening and closing or translocation of chromosomal regions over large distances in the nucleus 100,101 .”
Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact (2012, unknown): “Consistent with this model, loss of the H3K9me3 KMT in C. elegans results in detachment of an integrated complex array from the nuclear lamina and loss of lamin from regions normally associated with the nuclear lamina (Towbin et al., 2012).”
LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. (2013, background): “Targeting depends on histone methylation (Towbin et al., 2012)—that is, using the same repressive epigeneticmarks that LBR binds to in mammals.”
Single-cell dynamics of genome-nuclear lamina interactions. (2013, background): “Importantly, a recent study in C. elegans also found evidence for a role of H3K9 methylation in the targeting of genomic regions to the NL (Towbin et al., 2012).”