Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

By A. Dinkova-Kostova, M. Massiah, R. Bozak, R. J. Hicks, P. Talalay. Proceedings of the National Academy of Sciences of the United States of America, 2001

599 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0871d06b5f3097a79a96ae997e8dbe39ab810875

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Citations in the corpus

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress (2003, background): “One attractive mechanism is based on the fact that chemicals which enable Nrf2 to escape Keap1-mediated repression share a common propensity to react with protein thiols (9).”
Elucidating mechanisms of drug-induced toxicity (2005, background): “What other pathways is this system linked to? Which pathways are beneficial to the cell and which are detrimental? An assay for KEAP1 activation might be useful in the prediction of drug toxicity, but one must bear in mind that many beneficial compounds are believed to exert their effects by stimula”
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer (2007, background): “In turn, this reaction activates the 'phase 2' response, an intrinsic mechanism used by cells to deactivate electrophilic or oxidative stres”
Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders (2010, unknown): “9), another naturally occurring inducer of the Keap1 = Nrf2 = ARE pathway (151, 153), is also a subject of intense investigations (101, 102, 106).”
Role of nrf2 in oxidative stress and toxicity. (2013, background): “Dinkova-Kostova AT, Fahey JW, Talalay P. Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1).”
Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1 (2006, background): “As for the molecular mechanisms of oxidative and electrophilic stress detection, it has been proposed that various inducers of Nrf2 have the common chemical property of reacting with the sulfhydryl groups of cysteine residues (7).”
The cytoprotective role of the Keap1–Nrf2 pathway (2011, unknown): “Thus, bis(2-hydroxybenzylide)acetone is *30-fold more potent than trans-4-(2-hydroxyphenyl)-3buten-2-one (Dinkova-Kostova et al. 1998, 2001).”