Elucidating mechanisms of drug-induced toxicity

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Modeling polypharmacy side effects with graph convolutional networks (2018, background): “While the use of multiple drugs may be a good practice for the treatment of many diseases (Liebler and Guengerich, 2005; Tatonetti et al., 2012), a major consequence of polypharmacy to a patient is a much higher risk of side effects which are due to drug-drug interactions.”
Applications of nanoparticle systems in drug delivery technology (2017, background): “Numerous new medications have been developed to effectively treat complicated conditions, but at the same time some of them produce severe side effects that the benefit does not always outweigh the risk (Liebler and Guengerich, 2005).”
Molecular targeted therapy: Treating cancer with specificity (2018, background): “Drug toxicity can happen in different contexts as a result of drug overdose, drug-drug interaction, and adverse effects at therapeutic doses or rare idiosyncratic reactions (Liebler and Guengerich, 2005).”
A side effect resource to capture phenotypic effects of drugs (2010, background): “That is, on one hand, drugs can have off-targets in other tissues and, on the other hand, the main targets themselves can be expressed in different tissues or have effects in other tissues (Liebler and Guengerich, 2005).”