Regulatory T cells in autoimmmunity*.

By E. Shevach. Annual Review of Immunology, 2000

1,381 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0859b22ec3d4493b9fd088a493c560876f2084ed

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In Immunology

Citations in the corpus

An essential role for Scurfin in CD4+CD25+ T regulatory cells (2003, background): “gif" NDATA ITEM> ]> Many signaling pathways are involved in the activation and the control of T cell responses, but T R cells are clearly important in these processe”
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation (2003, background): “CD4 + CD25 + regulatory T cells (T reg ) are pivotal for the maintenance of self toleranc”
Regulatory T cells and mechanisms of immune system control (2004, background): “In addition the major histocompatibility (MHC) antigen thought to be their restriction element, I-J, was not found as expected in the MHC locus, and many suppressor T-cell clones were also found to not express a T-cell receptor (TCR”
Tolerance, not immunity, crucially depends on IL-2 (2004, background): “IL-2 is essential for T Reg cells T Reg cells are a minor subpopulation of T cells that develop in the thymus and migrate to the periphery, where their main role is to suppress self-reactive T cells that escape negative selection in the thymu”
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer (2008, background): “CD4 + CD25 + regulatory T (T reg ) cells seem to be essential for limiting organ-specific autoimmune disease”
Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance1 (2001, background): “The immunosuppressive activity of CD4 CD25 regulatory cells does not ap pear to depend on soluble factors, but to require cell contact, possibly involving signaling via CD152 (CTLA-4), a CD28 homologue expressed on activated T cells (1).”
A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis (2001, positive): “CD25 CD4 T cells of undefined antigen specificity perform a regulatory function in inhibiting autoimmunity (25, 26) while CD4 T cells specific for CNS antigens function as effector cells in inducing EAE.”
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3 (2005, methodology): “Using this model or models of lymphopenia-induced autoimmunity, several groups made critical observations demonstrating that specific CD4 + T cell subsets, fractionated based on expression of various cell surface markers, including CD5 and CD45RB, are capable of preventing autoimmune diseas”
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells 1 (2004, methodology): “These findings are not incompatible with the hypothesis that control of cell numbers in vivo in lymphopenic mice and possibly intact mice, may first be subject to other mechanisms of regulation before a participation of IL-10 is evoked in suppression (3, 5, 36, 52).”
Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function (2001, background): “Human CD25 CD4 Tr cells are anergic, fail to produce IL-2, constitutively express CTLA-4, and suppress the proliferation of naive CD4 T cells as described for murine CD25 CD4 Tr cells (2, 3).”
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival (2004, background): “Discussion Emerging evidence suggests that T reg cells, particularly CD4 + CD25 + T reg cells, are key mediators of peripheral toleranc”