An essential role for Scurfin in CD4+CD25+ T regulatory cells

By R. Khattri, T. Cox, Sue-Ann Yasayko, F. Ramsdell. Nature Immunology, 2003

3,163 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/61f5a90002a6e40339b9b6b96803c791f5340612

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Citations in the corpus

Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “In mice, expression of a Foxp3 transgene facilitated suppressor activity of CD8 T cells (25).”
Regulatory T cells exert checks and balances on self tolerance and autoimmunity (2010, background): “Such CD25 + CD4 + natural T reg cells specifically express FoxP3, a transcription factor essential for their development and functio”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “Importantly, Foxp3 was identified as a lineage-defining transcription factor for Tregs in mice (Fontenot et al., 2003; Hori et al., 2003; Khattri et al., 2003) and humans (Yagi et al.”
Regulatory T cells in autoimmune diseases (2018, background): “In vivo, activation of PI(3)K–Akt by Treg cell–specific deletion of the PI(3)K phosphatase PTEN elicits a type 1 autoimmune disorder, with Treg cells downregulating their expression of CD25 and Foxp3 and displaying reduced functionality100,101.”
Autosomal-dominant immune dysregulation syndrome in humans with CTLA4 mutations (2014, positive): “In mice, deficiency of CTLA-4 results in a lethal autoimmune phenotype 10,11 with marked similarities to IPEX in humans 7,12,13 .”
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. (2007, background): “Later, such cells were found to express the forkhead-winged helix transcription factor, Foxp3 (Khattri et al., 2003; Fontenot et al., 2003; Hori et al., 2003).”
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 (2007, background): “An X chromosome–encoded member of the forkhead winged-helix family of transcription factors, Foxp3, is specifically expressed in the subset of CD4 + T lymphocytes known as regulatory T cells (T reg cells”
Deacetylase inhibition promotes the generation and function of regulatory T cells (2007, background): “The devastating autoimmune disease found in humans and mice lacking Foxp3 demonstrates the importance of T reg cells in immune homeostasi”
Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans (2006, background): “Subsequent studies demonstrated that scurfy mice completely lack CD4CD25 Tregs and that adoptive transfer of this missing population can correct the autoimmune phenotype (60, 61).”