A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

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Mammalian Krüppel-Like Factors in Health and Diseases (2010, background): “KLF10 has an important role in the development of CD4 CD25 regulatory T (Treg) cells, which maintain self-tolerance and immune suppression (138).”
The gut microbiome shapes intestinal immune responses during health and disease (2009, neutral): “The development and function of T Reg cells is thought to be controlled by the transcription factor forkhead box P3 ( FOXP3 ), the absence of which results in massive multiorgan lymphoproliferative diseas”
A two-step process for thymic regulatory T cell development. (2008, background): “Natural regulatory T (Treg) cells play an important role in the preservation of self-tolerance (Fontenot and Rudensky, 2005; Izcue et al., 2006; Sakaguchi, 2004).”
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease (2007, background): “The most specifi c T reg cell marker currently known is the forkhead box transcription factor Foxp3, which has been shown to be expressed specifi cally in mouse CD4+ T reg cells and acts as a master switch in the regulation of their development and function (10).”