Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst

By D. Strumpf, C. Mao, Y. Yamanaka, A. Ralston, K. Chawengsaksophak, F. Beck, Janet Rossant. Development, 2005

1,190 citations recorded by the source corpus.

Subfields: Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/07701d5ca7bddcebce47aa613b5ba2cf652b6e9d

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Citations in the corpus

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (2010, background): “Exceptions to this were several key regulatory genes of embryonic and extra-embryonic differentiation, such as Cdx2 , Elf5 and Bmp4 , that were repressed during spermatogenesis and oogenesis but became activated in the early embry”
Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse (2009, background): “…mutant cells are not excluded from the TE layer in chimeric blastocysts (Ralston and Rossant, 2008), but in embryos carrying this mutation, the outer epithelium of the blastocyst loses morphological integrity and the cells do not undergo further trophoblast differentiation (Strumpf et al., 2005).”
Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. (2005, neutral): “This model can also explain why Oct3/4 is reexpressed in TE-like cells in Cdx2 null embryos (Strumpf et al., 2005) and why TE markers are expressed in the inner cells in Oct3/4 null embryos (Nichols et al.”
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. (2009, background): “These observations are consistent with our analysis of Tead4 mutant embryos (Nishioka et al., 2008), and with the fact that the Tead4 mutant phenotype is more severe than loss of Cdx2 alone (Strumpf et al., 2005).”
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. (2010, background): “The transition to the morula sees the upregulation of two key TE TFs, Gata3 and Cdx2 (Home et al., 2009; Ralston et al., 2010; Strumpf et al., 2005).”
Efficient differentiation of human embryonic stem cells to definitive endoderm (2005, background): “Finally, the robust upregulation of either SOX7 and CDX1 , or CDX2 and HCG , solely in the BMP4/SU5402-treated cultures suggests that hES cells have the potential to differentiate to primitive endoderm and trophectoderm, respectively, under appropriate condition”
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes (2013, neutral): “To test this idea, we reduced the levels of Oct4 transcription using shRNAs, which leads to activation of the trophectoderm master transcription factor Cdx2 and cellular differentiation (Figure 3C)(Deb et al., 2006; Niwa et al., 2005; Strumpf et al., 2005).”
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells (2007, background): “Differentiation into trophoectoderm is normally accompanied by upregulation of Cdx2 , which is necessary for proper trophoectoderm differentiation in early embryo”
Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo (2009, background): “Specification and maintenance of the trophectoderm in murine embryos are dependent upon activation of a sequence of transcription factors, including Tead4, Cdx2 and eomesodermin (Eomes) (Nishioka et al., 2009; Strumpf et al., 2005; Voss et al., 2000; Yagi et al., 2007).”