The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.

By R. Cao, Yi Zhang. Current Opinion in Genetics and Development, 2004

961 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/064136884db6dfb863a1d29c96a6a398141582c5

How researchers see this paper

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In Molecular Biology

1. Peter A. Jones
2. J. Simon
3. K. Helin
4. Yi Zhang
5. Martin Sauvageau
6. G. Sauvageau
7. A. Bracken
8. Manel Esteller

Citations in the corpus

• Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity (2004, background): “These modifications are dependent on the integrity of the EZH2 SET domain, and are believed to result in transcriptional repression of target genes (Cao and Zhang, 2004; Kuzmichev et al, 2004).”
• DZNep Is a Global Histone Methylation Inhibitor that Reactivates Developmental Genes Not Silenced by DNA Methylation (2009, background): “enhancer of zeste homologue 2 (EZH2), is responsible for the trimethylation of histone H3K27 (H3K27me3), which is a repressive chromatin mark (8).”
• The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. (2007, background): “A second complex, PRC2, contains the histone methyltransferase EZH2, which together with EED and SUZ12 trimethylates histone H3 on Lys 27 (H3K27me3) (Cao and Zhang 2004; Pasini et al. 2004b).”
• Structure and function of WD40 domain proteins (2011, background): “In addition to Hox gene silencing, the Polycomb Group complexes are also involved in X-inactivation, germline development, stem cell pluripotency and differentiation, and cancer metastasis ( Cao and Zhang, 2004 ).”
• DNA methylation and histone modifications: teaming up to silence genes. (2005, background): “Methylated K27 serves as an anchorage point for the PRC1 complex, the binding of which leads to transcriptional repression [30] through mechanisms that are still poorly understood.”
• The diverse functions of histone lysine methylation (2005, background): “The histone methyltransferase SET8/PR-Set7 catalyses the monomethylation of H4-K20 REFS 122124 .”
• Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. (2006, background): “Interestingly, the HPC proteins of the PRC1 complex can specifically bind to tri-methylated H3K27 (H3K27me3) (Cao and Zhang 2004; Kuzmichev et al. 2004; N. Dietrich, K. Helin, and K.H. Hansen, unpubl.).”
• Roles of the EZH2 histone methyltransferase in cancer epigenetics. (2008, background): “Among the histone modifications associated with gene silencng and cancer, much has been learned recently about the enzymes esponsible for methylation of histone lysine residues [2,8,12].”
• SWI/SNF nucleosome remodellers and cancer (2011, background): “PcG proteins are responsible for the trimethylation of lysine 27 in histone 3, thus establishing a silencing mar”
• DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation. (2006, background): “Polycomb group (PcG) proteins, which function in large complexes to methylate histones and modify chromatin (Cao and Zhang, 2004), maintain allele-specific silencing of some imprinted genes (Delaval and Feil, 2004).”