Roles of the EZH2 histone methyltransferase in cancer epigenetics.

By J. Simon, C. Lange. Mutation research, 2008

886 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c47050fbcda9bd5f6f59219dcb636945e1c66bf5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. M. Kulis
2. J. Simon
3. Xiaohua Shen
4. Robert E. Kingston
5. Jeremy N. Rich
6. K. Sarma
7. M. Lemieux
8. Jeannie T. Lee

Citations in the corpus

• Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put (2013, background): “The importance of dissecting PcG mechanisms is heightened by an expanding body of literature that implicates PcG machinery in gene regulatory networks gone awry in cancer cells (reviewed in Baylin and Jones, 2011; Bracken and Helin, 2009; Mills, 2010; Simon and Lange, 2008).”
• DNA methylation and cancer. (2010, background): “Second, the proposed interplay between PcG proteins and DNA methylation events may lead to the designation of a target sequence for methylation (Simon and Lange, 2008).”
• SWI/SNF nucleosome remodellers and cancer (2011, background): “For example, the expression of PcG protein EZH2 is frequently elevated in a wide range of cancers, including breast cancers, prostate cancers and lymphomas, and this overexpression is often correlated with advanced stages of disease progression and a poor prognosi”
• Genome-wide identification of Polycomb-associated RNAs by RIP-seq (2010, background): “Because misregulation of Polycomb proteins is often associated with cancer, we intersected PRC2-interacting RNAs with oncogene and tumor suppressor loci (Sparmann and van Lohuizen, 2006; Bernardi and Pandolfi, 2007; Miremadi et al., 2007; Rajasekhar and Begemann, 2007; Simon and Lange, 2008).”
• Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation (2010, background): “Proteins from the Polycomb group (PcG) contribute to epigenetically based gene silencing during development and evidence is emerging to suggest that they may serve important roles during oncogenic transformation (Bracken and Helin, 2009; Simon and Lange, 2008).”