Endothelial-mural cell signaling in vascular development and angiogenesis.

By Konstantin Gaengel, G. Genové, A. Armulik, C. Betsholtz. Arteriosclerosis, Thrombosis and Vascular Biology, 2009

926 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0629831cb88d1e884c618b93fb3ff713d9bab827

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Citations in the corpus

Basic and therapeutic aspects of angiogenesis. (2011, neutral): “Pericyte Recruitment Recruitment of mural cells is controlled by platelet-derived growth factor (PDGF) receptor-b (PDGFR-b) (Gaengel et al., 2009) (Figure 5A).”
Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions. (2013, background): “Multiple ligand-receptor complexes are known to be involved in the intercellular signaling between the two cell types: PDGF subunit B (PDGF-B)/PDGFRb, angiopoietin 1 (Ang-1)/tyrosine kinase receptor (Tie-2), stromal cell-derived factor-1 (SDF-1a)/C-X-C chemokine receptor type 4 (CXCR4), heparin bind”
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases (2011, background): “This growth factor is released from sprouting endothelial cells, which chemoattracts pericytes that express PDGFR”
Hallmarks of cancer: the next generation. (2011, positive): “…pericyte coverage of tumor vessels, which in turn desta-bilizes vascular integrity and function (Pietras and Ostman, 2010; Raza et al., 2010; Gaengel et al., 2009); interestingly, and in contrast, the pericytes of normal vessels are not prone to such pharmacological disruption, providing…”
Molecular mechanisms and clinical applications of angiogenesis (2011, background): “To stabilize endothelial cell channels, angiogenic endothelial cells release PDGF-B to chemoattract PDGF receptor-β (PDGFR-β) + pericyte”
Skin Acute Wound Healing: A Comprehensive Review (2019, neutral): “[141], forming new stable blood vessels [138, 142, 143].”
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “…cell typesor cocultures to in vivowork utilizinggain- and loss-of-function genetic approaches have demonstrated the pivotal role of TGFb signaling,membersof theTGFb signalingpathway, andupsteam regulators and modifiers of TGFb signaling in vascular development (reviewed by Gaengel et al., 2009).”
Hallmarks of cancer: interactions with the tumor stroma. (2010, background): “A range of signaling pathways, including PDGF, transforming growth factor (TGF)-β, angiopoietin and Notch family members, are implicated in pericyte recruitment, differentiation and function [10].”
Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging (2010, background): “Much of the insight into brain pericyte biology arose from devel- opmental studies and the analysis of pericyte-deficient transgenic mice with disrupted PDGF-B/PDGFRb signaling (Lindahl et al., 1997; Lindblom et al., 2003; Tallquist et al., 2003; Gaengel et al., 2009).”
Central nervous system pericytes in health and disease (2011, background): “Signaling: platelet-derived growth factor B The cross-talk and functional coupling between pericytes and endothelial cells is the result of several signal transduction cascades, including but not limited to platelet-derived growth factor B (PDGF-B), transforming growth factor-β (TGF-β), Notch, sp”