The mitochondrion in apoptosis: how Pandora's box opens

By N. Zamzami, Guido Kroemer. Nature reviews. Molecular cell biology, 2001

1,119 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/05c607d5618bd82bd2e67408d1c9664994469a74

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Citations in the corpus

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. (2004, background): “, exposure to proapoptotic stimuli that promote rapid 2000) and results in both matrix swelling and disruption dissociation of hexokinase from mitochondria potently of mitochondrial function and integrity (reviewed in [Marinduce cytochrome c release and apoptosis, even in tinou and Green, 2001; Zamz”
Mitochondrial reactive oxygen species in cell death signaling. (2002, background): “[6] N.”
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death (2007, background): “On the basis of biochemical evidence the standard model for the MPT pore consists of VDAC in the outer mitochondrial membrane, ANT in the inner mitochondrial membrane and cyclophilin D in the matrix (2-4,25,26).”
Apoptosis and acute kidney injury. (2011, background): “Ultimately, the balance between pro- and anti-apoptotic forces (the ‘apoptotic rheostat’(43)) determines whether or not the cells die by opening ‘Pandora’s Box’—the outer mitochondrial membrane.(44) Mitochondrial membrane permeabilization is regulated by BCL2 family proteins that number at least 20 ”
The role of mitochondria in apoptosis. (2008, background): “org membrane can lead to matrix swelling, causing the rupture of the outer mitochondrial membrane and release of cytochrome c (53, 54).”
Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “114,115 The process of apoptosis leads to a dramatic reorganization of mitochondrial networks into punctate spheres rather than long interconnected tubules.”
Cytotoxic T lymphocytes: all roads lead to death (2002, background): “Although the exact mechanism of cytochrome c release is somewhat controversial, both BAX and BAK have been implicate”
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. (2004, background): “…92037 Nur77 (TR3 or NGFI-B), an orphan member of the steroid/thyroid/retinoid nuclear receptor superfamily (Kastner et al., 1995; Mangelsdorf and Evans, 1995; Zhang, 2002), plays roles in regulating growth and apo-Summary ptosis (Winoto and Littman, 2002; Zamzami and Kroemer, 2001; Zhang, 2002).”
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer (2008, background): “Suppressing the entry of pyruvate into the mitochondria and thus the production of acetyl-CoA, will suppress both Krebs’ cycle and the ETC and thus MTP opening and apoptosis.”
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death (2005, background): “It has been suggested that the mPT plays a role in apoptotic mitochondrial membrane permeabilizatio”
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. (2007, background): “This further increases the production of mitochondrial ROS, likely reinforcing a positive feedback loop enhancing apoptosis (Zamzami and Kroemer, 2001).”