ICOS is essential for effective T-helper-cell responses

By A. Tafuri, A. Shahinian, F. Bladt, S. Yoshinaga, M. Jordana, A. Wakeham, L. Boucher, D. Bouchard, V. Chan, G. Duncan and 9 more. Nature, 2001

773 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/050ba583a6681c937afbcd9920d3cac443415cd0

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In Immunology

Citations in the corpus

FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION (2009, background): “ICOS-deficient humans and mice (Dong et al., 2001; McAdam et al., 2001; Tafuri et al., 2001) and ICOS-L-deficient mice have marked deficits in antibody production, isotype switch, and GC formation.”
Of Mice and Not Men: Differences between Mouse and Human Immunology (2004, background): “Whereas in mice the loss of ICOS does not affect either the number of mature B cells, their maturation status or their secretion of IgM (55, 56), the loss of ICOS in humans results in a severe reduction in B cell number, maturation status and secretion of IgM (57).”
Cytokine-secreting follicular T cells shape the antibody repertoire (2009, background): “Interactions between ICOS and its ligand, ICOSL, are required for GC formation and optimal antibody production but are not needed for the differentiation of T H 2 effector cells, for the migration of T H 2 effector cells to nonlymphoid tissue or for the recruitment of eosinophils to sites of infecti”
Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency (2003, background): “This concept proved correct with the establishment of a murine model in which the genomic deletion of Icos led to a disturbance of the humoral immune syste”
Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation (2014, background): “Several other costimulatory receptor-ligand combinations, including ICOS-ICOSL (Tafuri et al., 2001) and OX40OX40L (Jenkins et al.”
Germinal centres: role in B-cell physiology and malignancy (2008, background): “Besides the critical CD40–CD154 interaction, several other cell-surface receptors were found to transduce signals for the induction of CSR, including inducible T-cell co-stimulator (ICOS”