MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior.

By C. Roldo, E. Missiaglia, J. Hagan, M. Falconi, P. Capelli, S. Bersani, George A. Calin, Stefano Volinia, Chang-Gong Liu, A. Scarpa and 1 more. Journal of Clinical Oncology, 2006

797 citations recorded by the source corpus.

Subfields: Cancer Research, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/043f72956867038738b916b780acd4f94814248e

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Citations in the corpus

OncomiRs: the discovery and progress of microRNAs in cancers (2007, background): “Their results suggested that the alteration in miRNA expression was related to progression of malignancy [25].”
MicroRNA signature predicts survival and relapse in lung cancer. (2008, background): “Several microRNAs were reported to be associated with the clinical outcome of chronic lymphocytic leukemia (Calin et al., 2005), lung adenocarcinoma (Takamizawa et al., 2004; Yanaihara et al., 2006), and breast (Iorio et al., 2005) and pancreas (Bloomston et al., 2007; Roldo et al., 2006) cancers.”
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer (2008, background): “, 2007), proliferation (Roldo et al., 2006), antiapoptosis (Chan et al.”
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene (2008, background): “Recent reports have identified miR-21 as the only miRNA that is overexpressed in nine types of solid tumors (lung, breast, stomach, prostate, colon, brain, head and neck, esophagus and pancreas) (Chan et al., 2005; Iorio et al., 2005; Diederichs and Haber, 2006; Roldo et al., 2006; Volinia et al., 2”
Pathology and Genetics (2010, background): “Finally, global microRNA expression analysis revealed that the overexpression of a specific microRNA (miR-21) is strongly associated with an aggressive clinical behavior of PanNENs [37].”
MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. (2007, background): “Our laboratory recently reported on the miRNA expression patterns of 40 pancreatic endocrine tumors and 4 acinar carcinomas compared with normal pancreas.(21) In that study, 87 miRNAs were differentially overexpressed in tumors and 8 were underexpressed relative to normal pancreas.”
MicroRNA signatures in human cancers (2006, neutral): “gov/cancertopics/types/isletcell">endocrine pancreatic tumours”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “Subsequently, miR-21 overexpression was observed in a variety of human cancer, including those derived from breast, colon, liver, brain, pancreas and prostate [241, 274-279].”
MicroRNA function in cancer: oncogene or a tumor suppressor? (2009, background): “Studies using microarray analysis to compare miRNA expression in normals and pancreatic tumors [34] have shown increased expression of miR-103 and miR-107 in primary pancreatic tumors.”
miR-21: a small multi-faceted RNA (2008, background): “In pancreatic endocrine tumours, high miR-21 levels correlate with more aggressive tumours, as signified by an increased Ki67 proliferation index and the presence of liver metastases [66].”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “…apoptosis PTEN, TPM1 and PDCD4 Asangani et al. (2008); Chan et al. (2005); Frankel et al. (2007); Loffler et al. (2007); Meng et al. (2007a); Roldo et al. (2006); Si et al. (2007); Zhu et al. (2007) miR-29 Suggested to participate in maintaining proper DNA methylation Reduced levels in…”
MicroRNA signatures in human ovarian cancer. (2007, background): “In fact, the miRNA signatures obtained comparing different histotypes of ovarian carcinomas (serous, endometrioid, clear cell, and mixed) with the normal tissue are overlapping in most cases, but they also reveal a number of miRNAs that seem to be ‘‘histotype specific’’: the endometrioid tumors, for”