MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

By I. Asangani, S. A. K. Rasheed, D. Nikolova, J. Leupold, N. Colburn, S. Post, H. Allgayer. Oncogene, 2008

1,938 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8d37d0c762402578a795f6ede4693af0ef388eb0

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Citations in the corpus

Modulation of K-ras-dependent lung tumorigenesis by microRNA-21 (2010, positive): “PDCD4 is a proapoptotic tumor suppressor gene and has been verified as a miR-21 target in human colorectal and breast cancer cell lines (Afonja et al., 2004; Asangani et al., 2008; Bitomsky et al., 2008; Frankel et al., 2008; Lu et al., 2008; Zhang et al., 2006).”
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene (2008, background): “Another new report demonstrated an inverse correlation of miR-21 and Pdcd4 protein in colon cancer and showed that overexpression of miR-21 in Colo206f cells reduced Pdcd4 protein and increased invasion in a chicken embryo membrane assay (Asangani et al., 2007).”
A Pleiotropically Acting microRNA, miR-31, Inhibits Breast Cancer Metastasis (2009, neutral): “…that function as classical oncogenes or tumor suppressor genes (Ventura and Jacks, 2009), as well as a limited number that act at late stages of tumor progression (Ma et al., 2007; Tavazoie et al., 2008; Huang et al., 2008; Asan- gani et al., 2008; Zhu et al., 2008; Lujambio et al., 2008).”
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer (2017, neutral): “miR-21 PDCD4 Invasion and metastasis promotion [57]”
MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008, background): “Elevated miR-21 expression has been causally linked to proliferation, apoptosis, and migration of several cancer cell lines (1, 5, 44, 60).”
MicroRNAs in development and disease. (2011, background): “Among the miR-21 targets that were validated in CRC is the tumor suppressor programmed cell death 4 (PDCD4) (18).”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “In addition, an expression analysis of 217 Oncogene Table 1 miRNAs with relevance in cancer and cell death miRNA Normal function Cancer relevance Cell death relevance Targets References Let-7/miR-98 Upregulated late during Caenorhabditis elegans development; increased expression in differentiated ce”
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. (2008, background): “A known target of miR-21, PDCD4, showed a f30% decrease in luciferase activity (14, 15).”
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (2012, neutral): “The oncogenic miR-21 stimulates invasation, extravasation and metastasis in different tumour types, included colorectal cancer (Asangani et al, 2008) and breast cancer (Zhu et al, 2008), while oncosuppressor miR-205 has opposite effects, reducing invasion in vitro and suppressing lung metastasis in…”