Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

By Nigel J. Cairns, Eileen Bigio, I. Mackenzie, M. Neumann, V. Lee, K. Hatanpaa, C. White, Julie A. Schneider, Lea Teneholz Grinberg, G. Halliday and 13 more. Acta Neuropathologica, 2007

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Subfields: Neurology

View Paper: https://www.semanticscholar.org/paper/037b437b6440a903706d26044799c60f691e59b8

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Citations in the corpus

Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review (2010, background): “An indication of lower amyloid beta(1-40) levels in FTD compared with AD”
TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy (2010, background): “Frontotemporal lobar degeneration is also associated with MND and TDP-43 immunoreactivity, although FTLDTDP 43/MND is characterized by neuronal inclusions that are immunoreactive for ubiquitin but not tau (FTLD with taunegative ubiquitin-positive inclusions), and there are no tauimmunoreactive NFTs,”
Automatic classification of MR scans in Alzheimer’s disease (2008, background): “Although pathologically heterogeneous, FTLD can be neuropathologically separated from AD (McKhann et al., 2001; Cairns et al., 2007).”
ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function (2015, background): “Although there are data to support the notion that these aggregates may be amyloid like (Fang et al., 2014; Robinson et al., 2013), other evidence suggests that they are distinct from classical amyloids (Cairns et al., 2007; Dormann et al., 2009; Murakami et al., 2012).”
A new subtype of frontotemporal lobar degeneration with FUS pathology. (2009, background): “…type 3, familial with granulin gene (GRN) mutations, familial with valosin-containing protein (VCP) mutations and familial linked to chromosome 9p] (Cairns et al., 2007b); FTLD-tau [n = 8; including two each of Pick’s Disease (PiD), progressive supranuclear palsy (PSP), corticobasal degeneration…”
National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach (2011, neutral): “We refer the reader to recent consensus guidelines for the neuropathologic evaluation of FTLD and its subtypes [17, 34, 35], and issues important in the distinction of AD neuropathologic change from those of some forms of FTLD [58].”
National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease (2012, neutral): “For some tauopathies, such as tangle-predominant senile dementia (TPSD), chronic traumatic encephalopathy (CTE), or diffuse neurofibrillary tangles with calcification (DNTC), the distribution and density of tangles and the paucity of neocortical plaques must be carefully documented, since TPSD, CTE,”
Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease (2011, background): “Tau pathology in the absence of overt amyloid-β pathology is characteristic of a subset of frontotemporal dementia (FTD; also termed frontotemporal lobar degeneration, FTLD), which is the second most prevalent form of dementia occurring before the age of 65 (Ref”
Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship (2009, background): “8 directly trigger neurodegeneration: many germ line mutations in tau produce clinical dementia with NFTs (3, 6).”
Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. (2018, background): “…FTLD include focal atrophy within the cortical and subcortical networks that support language and behavioral regulation, which manifests microscopically as neuron cell death, microvacuolization, swollen neurons, white matter myelin loss, and gliosis within the affected areas (Cairns et al. 2007).”
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions (2010, background): “The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP”
Primary age-related tauopathy (PART): a common pathology associated with human aging (2014, background): “been grouped among FTLD subtypes [33] and there are”
Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy (2015, neutral): “Tau pathology is characterized as 3R or 4R predominant or mixed 3R + 4R type [12, 30, 32].”
The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy (2015, methodology): “The neuropathologists were given a tauopathy criteria guide that provided the provisional criteria for CTE [32] as well as published criteria for the other tauopathies (See supplementary material for full tauopathy criteria guide) [4, 7, 11, 21, 25, 34, 40, 47].”