Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases.

By Michael G. Erkkinen, Mee‐Ohk Kim, Michael D. Geschwind. Cold Spring Harbor Perspectives in Biology, 2018

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ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020, background): “Due to their debilitating nature and lack of any effective treatment, neurodegenerative diseases are a growing economic burden to society [1].”
Hallmarks of neurodegenerative diseases. (2023, neutral): “…NDD hallmarks (numbered) and their location in the modeled neuron and/or accompanying glial cells is presented for pathological protein aggregation (1), synaptic and neuronal network dysfunction (2), aberrant proteostasis (3), cytoskeletal abnormalities (4), altered energy homeostasis (5), DNA and…”
Clinical applications of stem cell-derived exosomes (2024, background): “176 Currently, only two classes of drugs are approved for symptomatic AD treatment, including cholinesterase inhibitors and NMDA antagonists.”