Frailty in older adults: evidence for a phenotype.

By L. P. Fried, C. Tangen, J. Walston, Anne B. Newman, Calvin Hirsch, J. Gottdiener, Teresa E. Seeman, Russell P. Tracy, W. Kop, Gregory Burke and 1 more. The journals of gerontology. Series A, Biological sciences and medical sciences, 2001

22,343 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/034c4ef512b58f93b6e12b161fffd38ad631435a

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Citations in the corpus

Survey of Health, Ageing and Retirement in Europe (SHARE) (2002, background): “Frailty is a geriatric syndrome that results from the accumulation of defects in various physiological systems (9,10).”
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age (2015, background): “Phenotypic characteristics of frailty include reduced muscle strength, poor endurance, and low physical activity (46).”
2024 ESC Guidelines for the management of elevated blood pressure and hypertension. (2024, positive): “405,406 Although the main determinant of frailty is age, chronological age must be differentiated from biological age.”
Effects of physical exercise interventions in frail older adults: a systematic review of randomized controlled trials (2015, methodology): “1 70 % women Institutionalized Fried’s criteria [2] Multi-component PRT”
Effects of Different Exercise Interventions on Risk of Falls, Gait Ability, and Balance in Physically Frail Older Adults: A Systematic Review (2013, positive): “5,6 The prevalence of frailty in people older than 65 years is high (ranging from 7% to 16.3%), increases with age, 7–9 and is the main risk factor for disability.”
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. (2013, neutral): “25, 27, 28) who are about to undergo medical procedures that increase inflammation and/or cellular senescence and that might push subjects into overt frailty or delirium.”
Evidence for the Domains Supporting the Construct of Intrinsic Capacity (2018, background): “At the same time, intrinsic capacity as part of the healthy aging model perhaps includes the biological state that underpins the frailty phenotype proposed by Fried and colleagues (72).”
Outcome instruments to measure frailty: a systematic review. (2011, background): “Even though the underlying mechanism of frailty is not fully understood, frailty is, since early publications, considered to be a physiologic loss of reserve capacity and resistance to stressors (Fried et al., 2001; Rockwood et al., 1994).”
Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. (2008, background): “3]); (2) weakness, as identified by grip strength in the lowest quintile stratified by body mass index quartile; (3) reduced energy level, as identified by an answer of “no” to the question “Do you feel full of energy?” on the Geriatric Depression Scale(25) (4) slowness, as identified by a walking s”
Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. (2002, background): “Similarly, Freid and coworkers have found higher disability and mortality rates in frail older adults, and their definition of frailty incorporates features that are associated with lower skeletal muscle mass, including grip strength, walking speed, weight loss, and sense of exhaustion (26).”
GLIM criteria for the diagnosis of malnutrition – A consensus report from the global clinical nutrition community (2019, background): “Impairment of muscle strength and function are core phenomena in conditions like sarcopenia,(15,16) cachexia,(5,6) and frailty.(20) Assessment of muscle strength should be an integral measure in assessment of patients with suspected sarcopenia since impairment of muscle strength is now recognized as”
Inflammation and frailty in the elderly: A systematic review and meta-analysis. (2016, result): “Similar findngs emerged when comparing frail vs. pre-frail/robust subjects in studies (Almeida et al., 2012; Arts et al., 2015; Comptè et al., 2013; ale et al., 2013) (SMD = 0.25, 95%CI: 0.02–-0.49, p = 0.04; I2 = 81%).”
Updating the Evidence for Physical Activity: Summative Reviews of the Epidemiological Evidence, Prevalence, and Interventions to Promote "Active Aging". (2016, background): “Given the centrality of weakness to the definitions of frailty (Fried et al., 2001; Liu & Fielding, 2011), PA and exercise programs in the oldest-old have often emphasized resistance training (also called strength training or weight lifting) as a direct antidote for sarcopenia (Chin, van Uffelen, Ri”