Inflammation and frailty in the elderly: A systematic review and meta-analysis.
By P. Soysal, Brendon Stubbs, Paola Lucato, C. Luchini, M. Solmi, Roberto Peluso, G. Sergi, A. Işık, E. Manzato, S. Maggi and 5 more. Ageing Research Reviews, 2016
942 citations recorded by the source corpus.
The pathogenesis of frailty and the role of inflammation is poorly understood. We examined the evidence considering the relationship between inflammation and frailty through a systematic review and meta-analysis. A systematic literature search of papers providing data on inflammatory biomarkers and frailty was carried out in major electronic databases from inception until May 2016. From 1856 initial hits, 35 studies (32 cross-sectional studies n=3232 frail, n=11,483 pre-frail and n=8522 robust, and 563 pre-frail+robust; 3 longitudinal studies n=3402 participants without frailty at baseline) were meta-analyzed. Cross-sectional studies reported that compared to 6757 robust participants, both 1698 frail (SMD=1.00, 95%CI: 0.40-1.61) and 8568 pre-frail (SMD=0.33, 95%CI: 0.04-0.62) participants had significantly higher levels of C-reactive protein (CRP). Frailty (n=1057; SMD=1.12, 95%CI: 0.27-2.13) and pre-frailty (n=4467; SMD=0.56, 95%CI: 0.00-1.11) were associated with higher serum levels of interleukin-6 compared to people who were robust (n=2392). Frailty and pre-frailty were also significantly associated with elevated white blood cell and fibrinogen levels. In three longitudinal studies, higher serum CRP (OR=1.06, 95%CI: 0.78-1.44,) and IL-6 (OR=1.19, 95%CI: 0.87-1.62) were not associated with frailty. In conclusion, frailty and pre-frailty are associated with higher inflammatory parameters and in particular CRP and IL-6. Further longitudinal studies are needed.
Subfields: Economics and Econometrics, Geriatrics and Gerontology, Physiology
View Paper: https://www.semanticscholar.org/paper/b9ccb25253e4a112ac9c023673a49743794ab590
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Citations in the corpus
- The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis (2017, background): “Frailty has characteristic molecular and physiologic features including increases in inflammatory markers [7] and epigenetic changes characterized by increased DNA methylation [8].”
- Relationship between depression and frailty in older adults: A systematic review and meta-analysis. (2017, background): “…partly explained by overlapping mechanisms such as cerebrovascular disease, chronic inflammation, oxidative stress, mitochondrial dysfunction (Brown et al., 2016), hypothalamicpituitary-adrenal (HPA) axis dysregulation (Belvederi et al., 2014), among others (Katz, 2004; Soysal et al., 2016, 2017).”
- Senescence and aging: Causes, consequences, and therapeutic avenues (2018, background): “Aging phenotypes such as frailty (Soysal et al., 2016) correlate with increased levels of proinflammatory factors.”
- Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease (2019, background): “Hazard ratios for serum CRP levels as well as IL-6 at baseline and risk of T2DM in male and female population were 1.26 (95% confidence interval (CI): 1.16-1.37) and 1.31 (95% confidence interval (CI): 1.17-1.46), respectively (22 cross-sectional studies, n = 40,735 subjects for CRP; 10 cross-sectio”