Mitochondrial signaling: the retrograde response.

By Ronald A. Butow, N. Avadhani. Molecules and Cells, 2004

886 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/02a9b69a76cc19c5d5d7843f378bcb0c9822e99c

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Citations in the corpus

Cancer as a metabolic disease (2010, background): “The primary role of the RTG response is to coordinate the synthesis of ATP through glycolysis alone or through a combination of glycolysis and glutaminolysis when respiratory function is impaired [110,111].”
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB (2012, background): “Another example is represented by the mitochondria retrograde signalling pathway, in which mitochondrial dysfunction activates factors such as NF k B, NFAT, and ATF, through altered Ca 2 þ dynamics (Butow and Avadhani, 2004).”
Transcriptional paradigms in mammalian mitochondrial biogenesis and function. (2008, background): “The Rtg pathway has not been identified in vertebrate cells, but there are a number of examples where the expression of nuclear genes is altered by deficiencies in mitochondrial function (31).”
Oxidation events and skin aging. (2015, background): “MtDNA deletions in fibroblasts lead to altered gene expression patterns through a retrograde pathway between mitochondria and the nucleus (Butow and Avadhani, 2004).”
Mitochondrial ROS signaling in organismal homeostasis. (2015, background): “, reduced ATP/energy charge), altered mitochondrial ROS (mtROS) production, or loss of mitochondrial membrane potential, with the precise outcome dictating the specific mitochondrial stress-signaling response (Butow and Avadhani, 2004; Sena and Chandel, 2012).”
Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence (2007, background): “Retrograde signalling includes up-regulation of mitochondrial biosynthesis via PGC-1 and PPAR-c, major metabolic and anti-apoptotic adjustments, and possible interaction with TOR signalling [27].”
Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae (2014, background): “While the expression of Gdh1 and Gln1 is mainly dependent on Gln3, the expression of enzymes of the TCA cycle devoted to the synthesis of a-ketoglutarate from oxaloacetate is instead controlled through what is known as the retrograde (RTG) signaling pathway (reviewed by Butow & Avadhani, 2004).”
Sirtuin Regulation of Mitochondria - Energy Production, Apoptosis, and Signaling (2010, background): “Subsequent increases in cytosolic free Ca2+ will activate calcineurin and several Ca2+-dependent kinases [52] and affect a wide variety of transcription factors to produce appropriate cell-specific transcriptional responses [53].”
Microautophagy: lesser-known self-eating (2011, positive): “Rtg1p, Rtg2p, and Rtg3p were originally found to mediate the mitochondria-to-nucleus pathway or retrograde response pathway, and sense the level of the glutamate and/or glutamine and hence the functionality of the mitochondria [41].”