Requirement of bic/microRNA-155 for Normal Immune Function

By Antony Rodríguez, E. Vigorito, S. Clare, M. Warren, P. Couttet, Dalya R. Soond, Stijn van Dongen, R. Grocock, P. Das, E. Miska and 6 more. Science, 2007

2,022 citations recorded by the source corpus.

MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155–deficient CD4+ T cells identified a wide spectrum of microRNA-155–regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/02a859733de4c53b1cc6306ec927abdec2377887

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Citations in the corpus

Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma (2008, background): “For example MIRN155, in addition to being upregulated in certain lymphomas but not others (Kluiver et al, 2005), is necessary for normal immune function (Rodriguez et al, 2007).”
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Metazoan MicroRNAs (2018, background): “…examine the molecular effects of perturbing a miRNA family not only confirm repression of many mRNAs with conserved sites but also reveal repression of even more mRNAs with non-conserved seed-matched sites (Krutzfeldt et al., 2005; Lim et al., 2005; Giraldez et al., 2006; Rodriguez et al., 2007).”
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Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract (2015, background): “Additionally, miR-155 was strongly upregulated in CT4 APCs and has been shown previously to be critical for APCs to effectively activate T cells (Rodriguez et al., 2007).”
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells through targeting SOCS1 (2009, background): “For example, miR155-deficent DCs fail to efficiently activate T cells, whereas miR155-deficient CD4 T cells exhibit increased Th2 cell polarization and produce high amounts of Th2 cell cytokines (Rodriguez et al., 2007; Thai et al., 2007).”
The Role of MicroRNAs in Human Diseases (2010, background): “Furthermore, miR-155 is reported to be required for B and T lymphocyte and dendritic cell function (89, 90) .”
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