The two NF-kappaB activation pathways and their role in innate and adaptive immunity.

By G. Bonizzi, M. Karin. Trends in immunology, 2004

1,080 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/023bdd97db01c96480adaeaee1cb438ff87394a6

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Citations in the corpus

• Macrophage plasticity and polarization: in vivo veritas. (2012, unknown): “TLR engagement leads to NF-κB activation and production of inflammatory mediators (27) associated with M1 macrophages.”
• The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance (2008, background): “Strong evidence demonstrates that levels of CCL2 are associated with TAM accumulation (2) and that CCL2 may play an important role in the regulation of angiogenesis (20).”
• NF-κB activation as a pathological mechanism of septic shock and inflammation (2006, unknown): “The IKK -dependent pathway mediates the activation of innate immunity and inflammatory responses (25), whereas the IKK -dependent pathway is involved in the termination and resolution of inflammatory responses (133).”
• Nitric oxide and peroxynitrite in health and disease. (2007, background): “An additional pathway involves NFκB, a crucial transcription factor involved in inflammatory and antiapoptotic signaling, which is activated in response to serine phosphorylation of an upstream kinase complex termed IKK (116).”
• Macrophage phenotypes in atherosclerosis (2014, background): “The activation of NF-jB by TLR ligands produces proinflammatory factors (89).”
• Regulation and Function of IKK and IKK-Related Kinases (2006, background): “activation of p52:RelB dimers, a response that is substantially slower than the activation of IκB-bound dimers (9).”
• Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor κB (2009, methodology): “In addition, an alternative pathway of NF- B activation, mainly involved in adaptive immunity, is activated by certain members of the TNF cytokine family but not by TNF- itself (7).”
• Role of tumor-associated macrophages in tumor progression and invasion (2006, background): “TNF-α, is a proinflammatory cytokine generally produced by macrophages in response to pro-inflammatory signals [59, 60].”
• Molecular mechanism and function of CD40/CD40L engagement in the immune system (2009, background): “The result is that both signaling pathways can lead and regulate different target genes (18).”