Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

By Khalid Al-Nedawi, B. Meehan, J. Micallef, V. Lhoták, Linda M. May, A. Guha, J. Rak. Nature Cell Biology, 2008

1,962 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0233177652e9db3f7d7955271e1b9242fe418d6a

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Citations in the corpus

Microvesicles: mediators of extracellular communication during cancer progression (2010, background): “(Dolo et al., 1998; Muralidharan-Chari et al., 2009a; Baj-Krzyworzeka et al., 2006) EGFR Receptor tyrosine kinase signal transfer (Al-Nedawi et al., 2008) VAMP3 v-SNARE (Muralidharan-Chari et al., 2009a) ARF6 Regulation of microvesicle release (Muralidharan-Chari et al., 2009a) HER2 Receptor signal…”
Exosomes: extracellular organelles important in intercellular communication. (2010, background): “[12] Al-Nedawi K, Meehan B, Micallef J, Lhotak V, May L, Guha A, Rak J.”
Exosomes Derived from Mesenchymal Stem Cells (2014, background): “Oncogenes can also be distributed by exosomes secreted from tumor cells [41].”
Exosomes in cancer development, metastasis, and immunity (2019, background): “Although other types of EVs, such as migrasomes, oncosomes and large oncosomes have also been associated with cancer development [12, 13, 16], their contributions will not be extensively discussed in this review, in the interest of focus and space.”
Exosomes and their roles in immune regulation and cancer. (2015, background): “[59] Al-Nedawi K, Meehan B, Micallef J, Lhotak V, May L, Guha A, et al.”
Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1 (2013, background): “Recent studies suggest that released vesicles may transfer functional RNA as well as transmembrane proteins contributing to the propagation of a transformed cell phenotype (9, 10, 14).”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “In addition, EVsmay induce changes in the cell phenotype by transfer to the target cell of functionally active receptors such as CCR5 (93), EGFRvIII (94) or MET (95).”
In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior (2015, result): “The provided proof here for the existence ofEV transfer between tumor cellswitha role in tumorprogression is supported by in vitro studies (Al-Nedawi et al., 2008; Demory Beckler et al., 2013; Higginbotham et al., 2011; O’Brien et al., 2013; Skog et al., 2008).”
Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression (2018, background): “It has also been shown that EVs derived from A431 squamous carcinoma cells can directly transfer oncogenic epidermal growth factor receptor (EGFR) to endothelial cells, leading to induction of angiogenesis (28).”
Exosomes in Tumor Microenvironment Influence Cancer Progression and Metastasis (2013, background): “The integration of EGFRvIII into these cells leads to an augmented expression of anti-apoptotic genes and an increase in anchorage independent growth capacity [32].”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “Tumor cells can also spread their intrinsic oncogenic portential to surrounding cells via EVs, as shown for an oncogenic variant of epidermal growth factor (EGF) receptor in glioblastoma cells (Al-Nedawi et al. 2008).”
Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkers (2008, background): “It has been shown that microvesicles can transfer some of their contents to other cell type”