Insulin Signaling in Health and Disease

By M. White. Science, 2003

899 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/0232e287b87f293f45f3713179c1fa842d868bf7

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Citations in the corpus

Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, positive): “Normally, when insulin binds to the insulin receptor on these cells, the insulin receptor is autophosphorylated at its Tyr residues and its tyrosine kinase is activated [3, 4].”
Mechanisms of type-I- and type-II-interferon-mediated signalling (2005, background): “These tyrosine residues are present in specific motifs such that, when phosphorylated, they function as binding sites for various signalling proteins that contain SH2 domains, including the p85 regulatory subunit of PI3”
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 (2012, background): “IRS2 (but not IRS1) protein concentration in mouse liver is decreased during refeeding via a PI3K-dependent mechanism [68].”
Glucagon-like peptide 1 (GLP-1) (2019, background): “Consistent with this role of Irs2, increased expression of Irs2 in b-cells improves insulin secretion in obese mice and protects against STZ-induced b-cell destruction (as reviewed in [547]).”
The JNK signal transduction pathway. (2007, background): “Pro-oncogenic Tumor suppression Ablation of the JNK pathway in mice can influence susceptibility to obesity and diabetes [82].”
Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics (2007, background): “type 2 insulin-independent diabetes, which are increasingly prevalent conditions [119–121].”
Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease (2014, background): “On the other hand, inhibitory serine phosphorylation (pSer) of IRS-1 and IRS-2, the best studied components of the IRS family, causes their dissociation from the IR and decreases tyrosine phosphorylation (pTyr) (60).”
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis (2006, background): “For example, the inappropriate inhibition of the PI3K pathway has been associated with diseases as diverse as diabetes and schizophreni”
FOXO3A genotype is strongly associated with human longevity (2008, background): “On the other hand, long-lived mice carrying mutations in either IRS-1 (58) or IRS-2 (23) are actually insulin resistant, so insulin sensitivity is not a necessary condition for mutations in the IIS pathway to be able to confer greater longevity.”