Mechanisms of type-I- and type-II-interferon-mediated signalling

By L. Platanias. Nature reviews. Immunology, 2005

3,584 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/11ce69c5c0de89cfcbf8dca1a0404cfa96aa5da2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Antoni Ribas
2. R. Randall
3. S. Goodbourn
4. K. Honda
5. Tadatsugu Taniguchi
6. Aubry Tardivel
7. Greta Guarda
8. P. Murray

In Oncology

1. Antoni Ribas
2. R. Randall
3. S. Goodbourn
4. Tadatsugu Taniguchi
5. K. Honda
6. P. Murray
7. Herbert W. Virgin
8. J. O’Shea

In Rheumatology

1. Tadatsugu Taniguchi
2. K. Honda
3. P. Murray
4. R. Randall
5. J. O’Shea
6. S. Goodbourn

Citations in the corpus

• Immunomodulatory functions of type I interferons (2012, background): “20 ) — that are constitutively associated with Janus kinase 1 (JAK1) and non-receptor tyrosine kinase 2 (TYK2”
• The multifunctional NS1 protein of influenza A viruses. (2008, background): “Indeed, PI3K activation has been implicated in many cellular functions that are also regulated by NS1, such as cytokine-downregulation in DCs, enhancement of mRNA translation and suppression of innate signalling pathways (Fukao & Koyasu, 2003; Platanias, 2005).”
• Type I interferon inhibits interleukin-1 production and inflammasome activation. (2011, background): “Tyrosine phosphorylation is required for nuclear translocation of STAT1 and transcription factor function (Platanias, 2005).”
• Primary resistance to PD-1 blockade mediated by JAK1/2 mutations (2016, background): “JAK kinases mediate signaling from many cytokine receptors, but the commonality between JAK1 and JAK2 homozygous loss of function mutations is that they are both required for signaling upon exposure to interferon gamma (27).”
• IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors (2006, background): “because it was first identified in the promoters of genes that are induced by signalling mediated by type I IFNs (that is, IFNα and IFNβ”
• Shared and Distinct Functions of Type I and Type III Interferons (2019, neutral): “In addition to the dominant JAK-STAT signaling response, both type I and type III IFNs can activate mitogenactivated protein kinase (MAPK) signaling (Platanias, 2005; Zhou et al., 2007).”
• Cytokine signaling modules in inflammatory responses. (2008, background): “The regulation of Stat1 activation by the interferon response, and its downstream effects has been comprehensively reviewed (Platanias, 2005; Shuai and Liu, 2003; van Hypothetical schematic of tissue-specific effects of Stat3 activation by the IL22R.”
• Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression (2017, neutral): “There, they bind to the GAS elements present in most interferon gamma inducible genes, such as the IRF1 gene (Platanias, 2005).”