Th17 and regulatory T cells in mediating and restraining inflammation.

By Dan R. Littman, Alexander Y. Rudensky. 2010

1,074 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Intestinal homeostasis and its breakdown in inflammatory bowel disease (2011, background): “Although TGF-β is required for the differentiation of both populations, the presence of STAT3-mediated signals (such as IL-6 or IL-23) promotes T H 17 cells at the expense of FOXP3 + T reg cell”
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. (2011, positive): “Subsequently, IL-23 and IL-21 play a key role in the maintenance of TH17 differentiation by enhancing the transcription of IL-17 and other TH17 signature cytokines (Korn et al., 2009; Littman and Rudensky, 2010).”
Innate IL-17-producing cells: the sentinels of the immune system (2010, background): “In addition, there are many checks and balances in this system to maintain mucosal homeostasis, and FOXP3 + regulatory T cells have an important role in opposing the effects of the IL-17-producing cell”
The Balance of Th17 versus Treg Cells in Autoimmunity (2018, background): “Thus, these two cell types play opposite roles during inflammatory and immune responses [6].”
MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development (2010, background): “Th17 and Th1 cells are hematopoietic cells that develop during tissue-specific inflammatory responses and play a pivotal role in enhancing inflammation (Littman and Rudensky, 2010).”
HIF Transcription Factors, Inflammation, and Immunity (2014, background): “…in the peripheral immune compartment is entwined with induction of Th17 CD4 + cells, as both rely on TGF-b, which can in turn promote expression of both RORgt and FOXP3; these latter are key transcription factors regulating the development of each respective cell type (Littman and Rudensky, 2010).”
Commensal Clostridia: leading players in the maintenance of gut homeostasis (2013, background): “CD4Foxp3 Tregs are the most prominent regulatory cells in the body and are most abundant in the colonic lamina propria [90,91].”
Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression (2011, background): “The presence of these Th17 cells within the tumor microenvironment could antagonize and counter the tumor-suppressive IFN-γ producing CD4+ Th1 cells (22, 24).”
HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells (2011, background): “T cell differentiation is programmed by coordinated induction of transcription factors and cytokine receptors to facilitate the establishment of specific lineages (Littman and Rudensky, 2010; Zhu et al., 2010).”
The Microbiome in Infectious Disease and Inflammation (2012, neutral): “Treg cells regulate immune responses through multiple mechanisms, including the expression of immune-suppressive molecules such as CTLA-4, IL-10, TGF-β, and IL-35, but also the depletion of ATP and IL-2 (28, 208).”