Human adipose tissue is a source of multipotent stem cells.

By P. Zuk, Min Zhu, Peter H. Ashjian, Daniel A. De Ugarte, Jerry I. Huang, H. Mizuno, Zeni C Alfonso, J. Fraser, P. Benhaim, M. Hedrick. Molecular Biology of the Cell, 2002

6,869 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/0074e7b7fef87bfeebebf2bc1a6095f1202c2d4e

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In Genetics

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In Physiology

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Citations in the corpus

• Adipose tissue-derived factors: impact on health and disease. (2006, background): “Lastly, adipose tissue is a reservoir of pluripotent stem cells (6).”
• Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue (2006, methodology): “Adipose tissue stem cells (ASCs), like bone marrow MSCs (BMSCs), differentiate in vitro toward the osteogenic, adipogenic, neurogenic, myogenic, and chondrogenic lineage when treated with established lineage specific factors [Zuk et al., 2001, 2002; Mizuno et al., 2002].”
• Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. (2004, background): “Cellular based tissue engineering approaches have increasingly used adult stem cells from different sources including bone marrow [39–42], trabecular bone [43], muscle [44], and adipose tissue [26,31–33,45–48].”
• Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. (2005, background): “Phenotypically, the starting cell material has been defined by a panel of surface markers, by subsequent adherence to plastic surface, and by their propensity to give rise to adipocytes, chondrocytes, and osteoblasts [7,12,23– 25,44,45].”
• Mechanisms and Metabolic Implications of Regional Differences among Fat Depots (2013, background): “They are multipotent, appearing to be capable of differentiating into macrophages, muscle or bone progenitors, brown fat, and other cell types (Figure 2A; Charrière et al., 2003; Rodriguez et al., 2004; Schulz et al., 2011; Zuk et al., 2002).”
• Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. (2004, background): “Adipose tissue may therefore serve as an easily available and abundant source of autologous stem cells for bone regeneration (Zuk et al., 2002; Dragoo et al., 2003; Lee et al., 2003).”
• Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC (2011, background): “AT-MSC (ASC) express CD49d, in contrast to BM-MSC; BM-MSC however, express CD106, which could not be detected in AT-MSC (ASC) [15].”
• Engineering cartilage tissue. (2008, background): “These cells are mesenchymal in origin, as determined by immunofluorescence and flow cytometry, and are capable of differentiating into chondrocytes in the presence of TGF-β, ascorbate, and dexamethasone in combination with a 3D culture environment [65,92].”
• Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. (2006, background): “Adult mesenchymal stem cells (MSCs) were proposed as an alternate cell source for transplantation because of their promising potential for proliferation and differentiation and their availability from different tissue sources (8,9).”