Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC
By R. Hass, C. Kasper, S. Böhm, R. Jacobs. Cell Communication and Signaling, 2011
1,614 citations recorded by the source corpus.
The mesenchymal stroma harbors an important population of cells that possess stem cell-like characteristics including self renewal and differentiation capacities and can be derived from a variety of different sources. These multipotent mesenchymal stem cells (MSC) can be found in nearly all tissues and are mostly located in perivascular niches. MSC have migratory abilities and can secrete protective factors and act as a primary matrix for tissue regeneration during inflammation, tissue injuries and certain cancers.These functions underlie the important physiological roles of MSC and underscore a significant potential for the clinical use of distinct populations from the various tissues. MSC derived from different adult (adipose tissue, peripheral blood, bone marrow) and neonatal tissues (particular parts of the placenta and umbilical cord) are therefore compared in this mini-review with respect to their cell biological properties, surface marker expression and proliferative capacities. In addition, several MSC functions including in vitro and in vivo differentiation capacities within a variety of lineages and immune-modulatory properties are highlighted. Differences in the extracellular milieu such as the presence of interacting neighbouring cell populations, exposure to proteases or a hypoxic microenvironment contribute to functional developments within MSC populations originating from different tissues, and intracellular conditions such as the expression levels of certain micro RNAs can additionally balance MSC function and fate.
Subfields: Genetics, Oncology, Surgery
View Paper: https://www.semanticscholar.org/paper/b53dd130de49ad4149f50bb60212c698b023b57d
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Citations in the corpus
- Silk fibroin as biomaterial for bone tissue engineering. (2016, background): “Readily accessible sources of adult MSCs are bone marrow, adipose tissue or peripheral blood, of which bone marrow mesenchymal stem cells (BMSCs) have been most studied [34].”
- Comparative Analysis of Human Mesenchymal Stem Cells from Bone Marrow, Adipose Tissue, and Umbilical Cord Blood as Sources of Cell Therapy (2013, positive): “Many authors have suggested that MSCs from neonatal tissues showed no sign of cellular senescence over long-term culture [32].”
- Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells (2012, neutral): “01% of the total marrow nucleated cells [134], whereas the amount of ASCs is approximately 500-fold greater when isolated from an equivalent amount of adipose tissue [135,136].”