Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

By R. DeMattos, K. Bales, D. Cummins, J. Dodart, S. Paul, D. Holtzman. Proceedings of the National Academy of Sciences of the United States of America, 2001

1,218 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/ff57da6eea6b9eb64e38897b7fbc890d9c5ad479

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

1. D. Selkoe
2. D. Walsh
3. G. Shankar
4. Martin Citron
5. D. Holtzman
6. Matthew Townsend
7. R. Swerdlow
8. P. Reddy

In Molecular Biology

1. D. Selkoe
2. D. Holtzman
3. David B. Teplow
4. G. Bitan
5. John C. Morris
6. T. Wyss‐Coray
7. Kurt M. Lucin
8. M. Kirkitadze

In Physiology

1. D. Selkoe
2. D. Holtzman
3. G. Shankar
4. Martin Citron
5. D. Walsh
6. David B. Teplow
7. B. de Strooper
8. John C. Morris

Citations in the corpus

• Alzheimer's disease: strategies for disease modification (2010, background): “The Aβ mid-region monoclonal antibody 266, which shows picomolar affinity to soluble Aβ and does not bind to plaques, was found to reduce amyloid levels upon passive administratio”
• Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: The emerging role of oligomeric assemblies (2002, positive): “This paradigm has provided the theoretical basis for recent therapeutic approaches demonstrating promise for amyloid elimination (Schenk et al., 2000; Cherny et al., 2001; DeMattos et al., 2001).”
• Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo (2006, background): “Several earlier studies have shown that some plasma Aβ can enter the CN”
• Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers (2006, background): “Injection of Aβ antibodies into adult APP transgenic mice can rapidly restore synaptic function without overt changes in histopathology (DeMattos et al. 2001; Dodart et al. 2002).”
• Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019, neutral): “It was hypothesized that the antibody might alter the equilibrium between plasma and CNS Aβ, the so-called “peripheral sink” hypothesis (DeMattos et al., 2001) as well as directly binding soluble Aβ in the CNS.”
• Immune activation in brain aging and neurodegeneration: too much or too little? (2009, background): “Alternatively, C3 may act in the periphery to clear circulating Ab by creating a peripheral sink, as previously proposed (DeMattos et al., 2001).”