Foreign body reaction to biomaterials.

By James M. Anderson, Analiz Rodriguez, David T. Chang. Seminars in Immunology, 2008

4,802 citations recorded by the source corpus.

Subfields: Biomaterials, Biomedical Engineering, Surgery

View Paper: https://www.semanticscholar.org/paper/5d9130a716b3944a4a8e3837645716e6d800584f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

In Biomedical Engineering

In Surgery

Citations in the corpus

Proangiogenic scaffolds as functional templates for cardiac tissue engineering (2010, methodology): “MΦ orchestrate the FBR by releasing cytokines and chemical mediators to attract other cells (endothelial cells, MΦ, fibroblasts) and to break down the implant (17).”
Progress Towards Biocompatible Intracortical Microelectrodes for Neural Interfacing Applications (2014, background): “Similar to the response in the rest of the body [84, 85], a key feature of the brain’s response to chronically implanted devices is persistent inflammation at the biotic-abiotic interface [99, 106].”
A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering. (2012, background): “Specifically, TE requires biomaterials that provoke cell interactions (wbioactivity) [103] and as little as possible adverse body reactions (wbiocompatibility) [104].”
Inspiration and application in the evolution of biomaterials (2009, background): “Early research and fortuitous accidents linking materials chemistry to biological response provided a rational basis for developing biologically inert substrates and provided a scientific foundation for biomaterials as an intellectually distinct disciplin”
Inflammation, Fracture and Bone Repair (2016, background): “In the lower row, an endo-osseous implant experimentwith a foreign body reaction (FBR) at the interface between host bone and the implant, leading to osseointegration.”
Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine (2012, background): “long-term implantable biomaterials [142].”
Corrosion of Metallic Biomaterials: A Review (2019, background): “Following implantation of biomaterials and medical devices, the following sequence of local events takes place: injury, blood-material interactions, provisional matrix formation, acute inflammation, chronic inflammation, granulation tissue development, foreign-body reaction (FBR) and fibrosis (fibro”
Macrophage Phenotype as a Determinant of Biologic Scaffold Remodeling (2008, neutral): “2 However, phenotypic and functional polarization of the mononuclear phagocyte cell population has recently been described, 3–6 which is similar to the Th1/Th2 polarization scheme of lymphocytes.”
Vascular Endothelial Cell Biology: An Update (2019, background): “These reactions can vary in intensity and severity, depending on the chemical and physical nature of the implanted materials [156].”
The Future of Biologic Coatings for Orthopaedic Implants (2013, background): “Insertion of an implant of any type within the body including bone evokes an inflammatory and (usually) limited foreign body reaction [56].”