The Future of Biologic Coatings for Orthopaedic Implants

By S. Goodman, Zhenyu Yao, M. Keeney, Fan Yang. Biomaterials, 2013

770 citations recorded by the source corpus.

Implants are widely used for othopaedic applications such as fixing fractures, repairing nonunions, obtaining a joint arthrodesis, total joint arthroplasty, spinal reconstruction, and soft tissue anchorage. Previously, orthopaedic implants were designed simply as mechanical devices; the biological aspects of the implant were a byproduct of stable internal/external fixation of the device to the surrounding bone or soft tissue. More recently, biologic coatings have been incorporated into orthopaedic implants in order to modulate the surrounding biological environment. This opinion article reviews current and potential future use of biologic coatings for orthopaedic implants to facilitate osseointegration and mitigate possible adverse tissue responses including the foreign body reaction and implant infection. While many of these coatings are still in the preclinical testing stage, bioengineers, material scientists and surgeons continue to explore surface coatings as a means of improving clinical outcome of patients undergoing orthopaedic surgery.

Subfields: Biomedical Engineering, Surgery

View Paper: https://www.semanticscholar.org/paper/891e3be3d2b8b40d1814ff8c1a2e084f09b9ed34

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In Biomedical Engineering

1. M. Surmeneva
2. R. Surmenev
3. S. Goodman
4. Mark Holodniy
5. A. Ivanova
6. N. Metoki
7. S. Heilshorn
8. Noam Eliaz

In Surgery

1. S. Goodman
2. Mark Holodniy
3. N. Metoki
4. S. Heilshorn
5. Noam Eliaz
6. J. Raphel

Citations in the corpus

• Antibacterial Coatings: Challenges, Perspectives, and Opportunities. (2015, background): “Several research teams have already undertaken the development of antibacterial agentreleasing coatings with various added properties, including increased wear resistance, corrosion resistance, anticoagulation, enhanced bone-integration, and improved overall tissue-integration [91–95].”
• Multifunctional Coatings to Simultaneously Promote Osseointegration and Prevent Infection of Orthopaedic Implants (2016, positive): “[11-18] However, the two issues are intimately related, as laid out by Gristina in his description of the “race for the surface”; if the host’s cells can reach and occupy the implan t surface first, not only will stronger tissue integration be achieved, but a defensive bar rier will also be establis”
• Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications (2017, background): “Therefore, in order to incorporate antibiotics into such coatings, a post-treatment has been implemented, usually by physical absorption [613].”
• Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis--a review. (2014, background): “Since all biomolecules within coatings should be released over time, any problems related to their storage and delivery must be solved [536].”