Energy metabolism in tumor cells

By R. Moreno-Sánchez, S. Rodríguez-Enríquez, Álvaro Marín-Hernández, E. Saavedra. The FEBS Journal, 2007

1,068 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fbf3cebd1a71f4ee678125523fde8bfe756f6cc2

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Citations in the corpus

Regulation of mammalian nucleotide metabolism and biosynthesis (2015, background): “However, hypoxic cells also ferment glucose to lactate, producing 2 ATP/mol glucose and in cancer cells glycolysis is typically accelerated many fold (42,121–122), which may produce ATP at a rate comparable to the more efficient mitochondrial oxidation of fuels including fatty acids (104,123), Gln (”
Glutamine Addiction: A New Therapeutic Target in Cancer (2010, background): “When first discovered, the high rate of aerobic glycolysis in cancer was felt to reflect mitochondrial dysfunction; however, a significant body of evidence supports that mitochondrial respiratory capacity is maintained in cancer [29].”
Cancer as a metabolic disease (2010, background): “Warburg's theory, however, was attacked as being too simplistic and not consistent with evidence of apparent normal respiratory function in some tumor cells [26-34].”
INHIBITION OF MITOCHONDRIAL TRANSLATION AS A THERAPEUTIC STRATEGY FOR HUMAN ACUTE MYELOID LEUKEMIA (2011, background): “Yet, more recent studies indicate that some tumors are highly dependent on oxidative phosphorylation for survival (Funes et al., 2007; Moreno-Sánchez et al., 2007; Rodrı́guez-Enrı́quez et al., 2006).”
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. (2008, background): “Indeed, many highly proliferative tumor cell lines that have been carefully studied do not have defects in oxidative metabolism (Moreno-Sanchez et al., 2007).”
Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review). (2012, background): “In their retrospective review, Moreno-Sánchez et al point out that although glycolysis plays an important role in cancer energy metabolism, a considerable amount of cancers use OXPHOS as a pathway of energy production or a mixture of glycolysis and OXPHOS (17).”
Causes and Consequences of Increased Glucose Metabolism of Cancers (2008, background): “Uterine, lung, breast, liver, and skin cancers all derive a significant amount of energy from oxidative phosphorylation (187).”
The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression (2019, background): “…Weinhouse (1956, 1976), Aisenberg (1961), Vaupel (1974, 1977), Shapot (1976), Shapot and Vaupel (1976), Zu and Guppy (2004), Kim and Dang (2006), Moreno-Sanchez et al. (2007), Christofk et al. (2008), Potter et al. (2016) and a series of other authors provided substantial evidence that…”
Oxidative Phosphorylation as an Emerging Target in Cancer Therapy (2018, background): “Reduction of oxygen consumption alleviates hypoxia The low oxygen concentrations in hypoxic regions of tumors may not be limiting for OXPHOS (2), and ATP is generated by OXPHOS in tumors even at very low oxygen tensions (13, 43).”
KRAS: feeding pancreatic cancer proliferation (2014, positive): “This observation was originally misinterpreted as evidence that cancer cells have defective mitochondria and impaired aerobic respiration, and are thus dependent on glycolytic metabolism; however, subsequent work has shown that mitochondrial function is not impaired in most cancer cells [23].”
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. (2011, positive): “However, it is now clear that respiration is not impaired in most cancer cells (Fantin et al 2006, Moreno-Sanchez et al 2007, Zu & Guppy 2004).”