The Effects of Early Rearing Environment on the Development of GABAA and Central Benzodiazepine Receptor Levels and Novelty-Induced Fearfulness in the Rat

By Christian Caldji, D. Francis, Shakti Sharma, P. Plotsky, Michael Joseph Meaney. Neuropsychopharmacology, 2000

597 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Social Psychology

View Paper: https://www.semanticscholar.org/paper/fb155f909ee63b3f1e10ed2ffc39e89c9c208ed9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

In Cellular and Molecular Neuroscience

In Social Psychology

Citations in the corpus

Variations in maternal care in infancy regulate the development of stress reactivity. (2000, background): “In earlier studies (Caldji et al 2000) we found that repeated periods of prolonged maternal separation resulted in decreased GABA A receptor binding, as well as diminished central (type I) benzodiazepine receptor levels.”
The Neurocircuitry of Fear, Stress, and Anxiety Disorders (2011, background): “…on fear/anxiety behavior is less convincing, however, as maternal separation in rat pups, which did alter relevant neurotransmitter systems, did not result in significantly enhanced startle response or decreased open field exploration as compared with non-separated animals (Caldji et al, 2000).”
The Neurobiology of Parental Behavior (2003, background): “Maternal separation has been associated with decreases in GABAa receptor density in LC, and decreases in benzodiazepine receptor density in LC and CNA (Caldji et al., 2000; Francis et al., 1999a; Ladd et al., 2000), which, as the authors indicate, should result in decreased inhibitory effects on the”
The enduring effects of abuse and related adverse experiences in childhood (2006, background): “Alterations in serotonergic (Rosenblum 1994; Bennett 2002) and GABAergic (Caldji 2000) receptors also contribute to deficits in social attachment and regulation of mood and affect following early stress.”
The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. (2001, background): “…abnormalities , including reduced consumption of a sweetened solution reflecting anhedonia, as well as increased freezing in an open-field, decreased exploration of a novel environment , and increased acoustic startle responses, all indicative of fear (Caldji et al 2000; Ladd et al 2000).”
Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity (2002, background): “In rodents or nonhuman primates, prolonged periods of maternal separation (MS) in early life increase the magnitude of neuroendocrine and fear responses to stress and thus vulnerability for stress-related illness (Higley et al., 1991; Plotsky and Meaney, 1993; Suomi, 1997; Hall et al., 1999; Caldji ”
Posttraumatic stress disorder: a state-of-the-science review. (2006, background): “, 2002) and GABAA receptor binding (Caldji et al., 2000).”
The neurobiological consequences of early stress and childhood maltreatment. (2003, background): “Early stress produces an enduring alteration in the subunit composition of the GABA-A supramolecular complex in the amygdala [26], subsequently reducing the density of both central benzodiazepine receptors and high affinity GABA-A receptors [26,27].”
Effects of early experience on group behaviour in fish (2007, background): “Thus the early rearing environment can influence the animal’s behavioural phenotype, and individuals exposed to different types of environment can develop different behaviours (Marler & Peters 1977, Wiltschko et al. 1987, Braithwaite & Guilford 1995, Caldji et al. 2000).”
Heritable and experiential effects on boldness in a tropical poeciliid (2007, background): “These results with domestic animals mirror those obtained in lab strains of mice and rhesus monkeys (Clarke 1993; Caldji et al. 2000).”