The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies.

By Christine Marcelle Heim, C. Nemeroff. Biological Psychiatry, 2001

2,775 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Clinical Psychology, Education

View Paper: https://www.semanticscholar.org/paper/ce5b4fa639ae86b1a49ad741f8ad690a64555023

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Citations in the corpus

The stress system in the human brain in depression and neurodegeneration. (2005, background): “Long-lasting hyper(re)activity of the CRH neurons, resulting in increased stress responsiveness and reflecting a glucocorticoid resistant state, is commonly seen in depressed individuals (De Kloet et al., 1997; Heim and Nemeroff, 2001; Pariante, 2003).”
Intergenerational Trauma: Convergence of Multiple Processes among First Nations peoples in Canada (2009, neutral): “Although the influence of recent stressors are most often considered in relation to pathology, distal events and prior episodes of depression are known to increase vulnerability to stress-related disturbances (Espejo et al., 2006; Hammen, Henry & Daley, 2000; Heim & Nemeroff, 2001).”
Stress and depression. (2005, neutral): “…has been an additional emphasis on the role of early exposure to childhood adversity, trauma, and abuse in promoting abnormalities of HPA axis activity that result in sensitization to the effects of later stressors (e.g., reviewed in Heim & Nemeroff 2001, Kaufman et al. 2000, Ladd et al. 2000).”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “period the development of an organism is subjected to complex environmental influences and that deleterious life events during development induce neurobiological and behavioral defects (207, 557, 569).”
Early life experience alters response of adult neurogenesis to stress (2004, neutral): “dtd" [ ]> Early life stress is associated with changes in behavior, physiological responses to stress and susceptibility to psychopathology in adult”
Cognitive Deficits in Depression and Functional Specificity of Regional Brain Activity (2007, background): “These regions have been related to endocrine function and the release of neurotransmitters and hormones in response to environmental stressors and are thought to be associated with the pathophysiology of mood disorders (Heim et al., 2000; Heim & Nemeroff, 2001).”