Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity

By D. Francis, J. Diorio, P. Plotsky, Michael Joseph Meaney. Journal of Neuroscience, 2002

687 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Education, Social Psychology

View Paper: https://www.semanticscholar.org/paper/2e1c880df0eb308202665a49addaf25b64e8b7fd

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Citations in the corpus

Sensitive Periods in the Development of the Brain and Behavior (2004, background): “Although the mechanisms activated by attention and arousal have been shown to enable large changes in the connectivity of adult circuits (Kilgard & Merzenich, 1998), it is unlikely that the changes that have been induced involve the same range of cellular and molecular changes as those that occur du”
The neurobiology of stress and development. (2007, background): “However, some effects appear to be responsive to postinfancy modification by placing the juvenile animal in complex environments that stimulate exploration and expose the animal to high levels of social stimulation and novelty (Francis et al. 2002).”
Evolution and ontogeny of stress response to social challenges in the human child (2006, background): “…hypothesis " ƒthe development of individual diVerences in behavioral and neuroendocrine responses to stress can be inXuenced by events occurring at multiple stages in developmentƒ " (Francis et al., 2002, p. 7843) Early experiences can have profound and permanent eVects on stress response.”
Heart rate variability as a measure of autonomic regulation of cardiac activity for assessing stress and welfare in farm animals -- a review. (2007, background): “In the past decade, HRV has also been applied increasingly in veterinary and behavioural research to investigate changes in sympathovagal balance related to pathological conditions [24–26], stress [27–31], behavioural dysfunction [32,33], management practices [34–36], training regimes [37–39] as wel”
Enriched environments, experience-dependent plasticity and disorders of the nervous system (2006, background): “Manipulations that modify stress levels by disrupting the early-rearing environment have been combined with environmental enrichment, for example, to show that enrichment can reverse the effects of maternal separation on both the hypothalamic-pituitary-adrenal (HPA) and behavioural responses to stre”
Neurobiological and psychiatric consequences of child abuse and neglect. (2010, background): “Preclinical studies suggest that deleterious effects of early trauma can be attenuated through enrichment in the environment later in life (Bredy et al., 2004; Charmandari et al., 2005; Francis et al., 2002).”
Epigenetics and the embodiment of race: Developmental origins of US racial disparities in cardiovascular health (2009, background): “Recent animal research has shown that environmental enrichment during adolescence can reverse some of the deleterious effects of early life epigenetic programming (Bredy et al., 2003; Francis et al., 2002; Laviola et al., 2004).”
Critical period regulation. (2004, background): “Reduced hippocampal spatial learning and elevated anxiety in the mature offspring of poor mothers can be rescued by fostering to good mothers or enriched environments (Francis et al. 2002).”
A Review of Adversity, The Amygdala and the Hippocampus: A Consideration of Developmental Timing (2009, positive): “Intervention during the adolescent phase of development may modify the behavioral effects of juvenile stress exposures in rodents (Francis et al., 2002), but does not alter the hippocampal pathology in adulthood associated with exposure to stress during the juvenile phase.”