Nanog safeguards pluripotency and mediates germline development

By Ian Chambers, José C. R. Silva, Douglas Colby, Jennifer Nichols, B. Nijmeijer, M. Robertson, J. Vrána, Kenneth Jones, L. Grotewold, Austin G Smith. Nature, 2007

1,600 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fafd02556f9f4d9ef26e9872576692133998709e

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Citations in the corpus

Naive and primed pluripotent states. (2009, background): “Interestingly, unlike Oct4, Nanog is dispensable once pluripotency has been attained in ESC cultures, although its absence reduces the threshold for differentiation (Chambers et al., 2007).”
The Transcriptional and Epigenomic Foundations of Ground State Pluripotency (2012, background): “In contrast, serumES cells are heterogeneous in morphology (Figure S2A) and expression of factors such as Nanog, Rex1, Stella, and Klf4 (Chambers et al., 2007; Hayashi et al., 2008; Toyooka et al., 2008; Figure S2B).”
Droplet barcoding for single cell transcriptomics applied to embryonic stem cells (2015, neutral): “Among the variable genes, we found pluripotency factors previously reported to fluctuate in ES cells ( Nanog , Rex1/Zfp42 , Dppa5a, Sox2, Esrrb ) but, notably, the most highly variable genes included known markers of PrEn fate ( Col4a1/2, Lama1/b1, Sox17, Sparc ), markers of Epiblast fate ( Krt8, Kr”
Cellular Decision-Making and Biological Noise: From Microbes to Mammals (2011, background): “, who showed stochastic Nanog expression corresponding to attempts of ES cell differentiation (Chambers et al., 2007), Kalmar et al.”
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. (2008, background): “, 1983), or heterogeneity of ES cells (Chambers et al., 2007).”
Nonequilibrium physics in biology (2019, background): “NANOG activates Oct-4, whereas Oct-4 activates NANOG at low and suppresses it at high levels, Fig.”
Control of Embryonic Stem Cell State (2011, background): “Although ESCs can be propagated in the absence of Nanog (Chambers et al., 2007), Nanog promotes a stable undifferentiated ESC state (Chambers et al.”
A double take on bivalent promoters. (2013, background): “Conventional mouse ES cell culture requires the presence of serum, and the heterogeneous expression of pluripotency factors and developmental regulators has been partly attributed to serum components (Chambers et al. 2007; Hayashi et al. 2008; Toyooka et al. 2008).”
Single-cell entropy for accurate estimation of differentiation potency from a cell's transcriptome (2017, background): “Although some of the observed intercellular transcriptomic variation represents stochastic noise, a substantial component has been shown to be of functional importance 1,5–8 .”
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration (2011, background): “However, if NANOG is removed from cells that have already attained pluripotency, they still retain many stem cell attribute”
Systems biology of stem cell fate and cellular reprogramming (2009, result): “Interestingly, another report (which was, in fact, published before the work of Chang and co-workers) has shown a remarkably similar phenomenon in mouse ES cell”