Epitope spreading in immune-mediated diseases: implications for immunotherapy

By C. Vanderlugt, S. Miller. Nature reviews. Immunology, 2002

956 citations recorded by the source corpus.

Subfields: Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/fa6003afa10d5946800b5658f65ca3b5e5330580

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In Immunology

1. V. Kuchroo
2. S. Miller
3. Howard L. Weiner
4. E. Bettelli
5. D. Cua
6. W. E. Paul
7. Jinfang Zhu
8. A. Jetten

Citations in the corpus

• Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis (2005, background): “Epitope spreading is the process by which reactivity to epitopes distinct from and non-crossreactive with the disease-inducing epitope is induced during chronic inflammatory processe”
• New concepts in the immunopathogenesis of multiple sclerosis (2002, neutral): “After the initial CNS tissue damage by autoreactive T cells, the release of myelin antigens could promote immune responses to additional myelin epitopes, starting a cascade of events that culminates in chronic diseas”
• HLA variation and disease (2018, background): “Moreover, even within a single individual, epitope spreading can either contribute to ongoing pathology or even have a protective effect 91 .”
• Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis (2003, background): “They may later develop relapsing-remitting disease because of epitope spreading (36).”
• Immunology of multiple sclerosis. (2005, neutral): “Upon EAE induction with whole spinal cord homogenate in SJL/J mice, the dominant T cell response is directed against PLP(139−151), and during disease relapses predictable epitope spreading occurs to PLP(178−191) and later to MBP(89−101) (130, 131).”
• Tumor antigen-specific T helper cells in cancer immunity and immunotherapy (2005, background): “Spreading of the immune response to other antigens, referred to as epitope or determinant spreading, is a phenomenon first discovered in the case of autoimmune disease [58].”