Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

By C. Rampon, Ya-ping Tang, J. Goodhouse, Eiji Shimizu, M. Kyin, J. Tsien. Nature Neuroscience, 2000

777 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/fa40536e2cbc3bd383f248197b5f4cb17804cd65

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. L. R. Squire
2. R. E. Clark
3. E. Bruel-Jungerman
4. Veronica A. Alvarez
5. Pierre Marie Lledo
6. J. Sweatt
7. Craig E. L. Stark
8. Stephen Maren

In Cognitive Neuroscience

1. L. R. Squire
2. R. E. Clark
3. S. Laroche
4. E. Bruel-Jungerman
5. Pierre Marie Lledo
6. J. Sweatt
7. Stephen Maren
8. Bernardo L. Sabatini

In Neurology

1. Pierre Marie Lledo
2. E. Bruel-Jungerman
3. C. Rampon
4. S. Laroche
5. J. Sweatt
6. Bernardo L. Sabatini
7. L. R. Squire
8. Fred H. Gage

Citations in the corpus

• Dendritic spine structural anomalies in fragile-X mental retardation syndrome. (2000, background): “Similarly, others have reported amelioration of genetically related behavioral defi-ciencies by exposing mentally retarded children to an ‘enriched’ toy and object filled environment (Horner, 1980) or rearing animals in a more ‘normal’ environment (Caston et al., 1999; Rampon et al., 2000).”
• New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment (2005, background): “In addition to increased neurogenesis, enhanced synaptogenesis has been observed in the dentate gyrus and areas CA3 and CA1 (Altschuler, 1979; Rampon et al., 2000).”
• Epigenetic mechanisms in memory formation (2005, background): “The formation of long-term contextual fear memories requires NMDA ( N -methyl- D -aspartate)-receptor-dependent synaptic transmission and the MEK–ERK/MAPK signalling cascade (where MEK referes to MAPK/ERK kinase) in the hippocampu”
• Neurobiology of Pavlovian fear conditioning. (2001, background): “Contextual fear conditioning deficits in hippocampal NMDA receptor–knockout mice are overcome by P1: FQP April 4, 2001 18:39 Annual Reviews AR121-29 918 MAREN environmental enrichment (Rampon et al 2000).”
• On Making Behavioral Genetics Truly Developmental (2003, background): “(For an outstanding example of the latter, see Rampon et al. [2000] .) Viewed in this way, developmental understanding or explanation is a multilevel affair involving at least culture, society, immediate social and physical environments, anatomy, physiology, hormones, cytoplasm, and genes.”
• Anatomical and physiological plasticity of dendritic spines. (2007, background): “…by Lewis 2004, Leggio et al. 2005), enrichment enhances long-term potentiation (LTP) in the hippocampus (Duffy et al. 2001), affect gene expression (Rampon et al. 2000, Lazarov et al. 2005), cell proliferation and survival (Altman & Das 1964, Szeligo & Leblond 1977, van Praag et al. 1999),…”
• The medial temporal lobe. (2004, result): “Similar findings were obtained after intrahippocampal injections of APV (Baker & Kim 2002) and in mice lacking the NMDAR-1 subunit in the hippocampal region (Rampon et al. 2000).”
• Impaired Recognition Memory in Rats after Damage to the Hippocampus (2000, background): “Finally, impaired performance on the VPC task has also been reported in mice lacking the NMDAR-1 subunit in the CA1 region of the hippocampus (Rampon et al., 2000).”