Dendritic spine structural anomalies in fragile-X mental retardation syndrome.

By Scott A. Irwin, R. Galvez, W. Greenough. Cerebral Cortex, 2000

652 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6b2f8410a056358f7ac3563722cc6b47fa22d1e3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Mark F. Bear
2. H. Zoghbi
3. Hong Zhang
4. J. Hutsler
5. Thomas Bourgeron

In Molecular Biology

1. H. Zoghbi
2. Mark F. Bear
3. Pierre Marie Lledo
4. Hong Zhang
5. J. Hutsler
6. C. Greer

Citations in the corpus

• Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders. (2010, methodology): “…et al., 1999; Dietzmann and von Bossanyi, 1994; Ferrer and Galofre, 1987; Fiala et al., 2002; Garey et al., 1998; Huttenlocher and Dabholkar, 1997; Irwin et al., 2000, 2001; Jacobs et al., 1997, 2001; Michel and Garey, 1984; Multani et al., 1994; Suetsugu and Mehraein, 1980; Swann et al., 2000).”
• Fragile X Mental Retardation Protein Regulates New Neuron Differentiation in the Adult Olfactory Bulb (2011, background): “The supernumerary spines in mutated GCs receive functional glutamatergic inputs Long and thin spines are often considered to be immature (Irwin et al., 2000).”
• Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. (2008, neutral): “Fragile X Phenotype Suggests FMRP Affects Dendritic mRNA Function A hallmark of the FXS neuroanatomical phenotype is the hyperabundance of dendritic spines with a long, thin, and otherwise immature morphology (Grossman et al., 2006; Irwin et al., 2000).”
• Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. (2012, background): “About one-third of the females with FXS have some ID. Postmortem neuropathological studies revealed structural abnormalities of dendritic spines (Comery et al. 1997; Irwin et al. 2000).”
• The Human Brain in Numbers: A Linearly Scaled-up Primate Brain (2009, neutral): “Across these individuals, other factors such as variations in number and identity of synaptic connections within and across structures, building on a statistically normal, albeit variable, number of neurons, and depending on genetics and life experiences such as learning, are more likely to be deter”