Anatomical and physiological plasticity of dendritic spines.

By Veronica A. Alvarez, Bernardo L. Sabatini. Annual Review of Neuroscience, 2007

662 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/4fcdfbd43fe4cdf63b1b09a53b6b1b0889a0dd1b

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Citations in the corpus

Complex brain networks: graph theoretical analysis of structural and functional systems (2009, background): “…is modified in the adult brain is highly debated. although some evidence suggests that mammalian cellular networks are continually remod-elled 93 , other evidence indicates that most synaptic spines are stable 94 . changes in neuronal connectivity necessitate homeostatic mechanisms to ensure…”
Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses (2011, background): “The excitatory synaptic connections are formed between axons and dendritic spines, which are complex and dynamic postsynaptic structures containing thousands of different proteins (Alvarez and Sabatini, 2007; Tada and Sheng, 2006).”
Emergence of network structure due to spike-timing-dependent plasticity in recurrent neuronal networks V: self-organization schemes and weight dependence (2010, background): “In biology, other mechanisms such as structural plasticity that creates and eliminates synapses (Alvarez and Sabatini 2007; Butz et al. 2009; Holtmaat and Svoboda 2009) also occur in parallel to the waxing and waning of existing synapses, which interplays with the organization scheme presented here.”
Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning (2011, background): “Tremendous progress has recently been made in elucidating cellular aspects of structural brain plasticity (Kempermann et al., 1997; Engert and Bonhoeffer, 1999; Holtmaat et al., 2005; De Paola et al., 2006; Haber et al., 2006; Alvarez and Sabatini, 2007) in the rodent.”
The Role of Microglia in the Healthy Brain (2011, background): “During microglial interaction, these spines transiently expanded, similar to synaptically active spines in vitro (Alvarez and Sabatini, 2007), with small spines showing the most pronounced changes.”
Synaptic Mechanisms for Plasticity in Neocortex (2009, background): “Strong evidence for LTP in adult cortical learning comes from V1, where presentation of temporally precise, flashed visual stimuli alters functional synaptic connectivity, visual receptive fields, and visual perception in a manner consistent with induction of spike timing–dependent LTP and LTD (disc”
Balancing structure and function at hippocampal dendritic spines. (2008, background): “Live imaging with twophoton microscopy has revealed rapid, activitydependent spine turnover common during development , but as an animal matures more spines stabilize (Alvarez & Sabatini 2007).”
Automated Three-Dimensional Detection and Shape Classification of Dendritic Spines from Fluorescence Microscopy Images (2008, background): “From a biophysical viewpoint, these effects give rise to increased synaptic currents and reduced time constants for calcium compartmentalization in larger spine heads (see refs [5,20] for review), modulating postsynaptic mechanisms that determine functions such as learning and memory [21–24].”