Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.

By P. Havel. Nutrition reviews, 2005

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Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence (2010, background): “Fructose intake may also lead to weight gain by decreasing production of insulin and leptin in peripheral tissues, thereby initiating the hunger cascade in the central nervous system [90].”
The SLC2 (GLUT) Family of Membrane Transporters (2013, neutral): “There has been much interest generated about fructose metabolism since correlations between increased consumption of dietary fructose and the rising incidence of type 2 diabetes mellitus, metabolic syndrome, and obesity in many countries became apparent (Havel, 2005).”
Metabolic effects of fructose and the worldwide increase in obesity. (2010, background): “As a whole, they indicated that high-fructose/high-sucrose diets lead to several adverse metabolic and cardiovascular effects, including dyslipidemia, insulin resistance, hypertension, hyperuricemia, and weight gain (24, 91, 123).”
Fructose consumption as a risk factor for non-alcoholic fatty liver disease. (2008, background): “Indeed, total fructose intake averages approximately 12% of total energy intake and may increase to 15% in some subgroups in the US population [15].”
Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress (2012, background): “Fructose is known to be lipogenic (6), and the feeding of fructose to rats causes the rapid development of fatty liver (7).”