The SLC2 (GLUT) Family of Membrane Transporters
By M. Mueckler, B. Thorens. Molecular Aspects of Medicine, 2013
1,215 citations recorded by the source corpus.
GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human and they are categorized into 3 classes based on sequence similarity. All GLUTs appear to transport hexoses or polyols when expressed ectopically, but the primary physiological substrates for several of the GLUTs remain uncertain. GLUTs 1–5 are the most thoroughly studied and all have well established roles as glucose and/or fructose transporters in various tissues and cell types. The GLUT proteins are comprised of ~500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 membrane-spanning domains. In this review we briefly describe the major characteristics of the 14 GLUT family members.
Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/5147ea111d5ac19cd215cfbbebb80374a7741939
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Endocrinology, Diabetes and Metabolism
In Molecular Biology
In Surgery
Citations in the corpus
- A cellular perspective on brain energy metabolism and functional imaging. (2015, background): “Indeed, neurons express glucose transporters of the GLUT3 type as well as hexokinase activity (Mueckler and Thorens, 2013; Zhang et al., 2014).”
- SLC Transporters as Therapeutic Targets: Emerging Opportunities (2015, neutral): “Members of the SLC2, SLC5 and SLC50 families are required for intestinal absorption and renal reabsorption of glucose and for glucose uptake into neurons, erythrocytes, hepatocytes and other cell types 13,14 .”
- Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels (2019, background): “Abbreviations DM diabetes mellitus GLUT glucose transporter HMIT myo-inositol transporter IRS insulin resistance substrate IR insulin receptor PTP protein tyrosine phosphatase PTEN tensin homologue FFAs free fatty acids TNF tumor necrosis factor SOCS suppressor of cytokine signaling IAPP islet amylo”
- GLUT2, glucose sensing and glucose homeostasis (2015, background): “Studies of the facilitated diffusion glucose transporters have revealed a multitude of novel regulatory systems controlling glucose homeostasis [17, 97].”
- Getting Across the Cell Membrane: An Overview for Small Molecules, Peptides, and Proteins (2015, background): “Sugars, including glucose, galactose, and fructose, are molecules of high polarity and intermediate size, and are imported into the cell by the glucose transporter (GLUT) family of facilitated transporters [60].”