Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization.

By Jason M. Casolari, Christopher R. Brown, Suzanne Komili, J. West, H. Hieronymus, Pamela A. Silver. Cell, 2004

626 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f95e8606cb31c781141f4d653050c3c22fdcd8f6

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In Molecular Biology

Citations in the corpus

Single-RNA counting reveals alternative modes of gene expression in yeast (2008, background): “Different studies have shown that many genes in yeast associate with the nuclear periphery when they are transcribe”
Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions (2007, background): “Indeed, the nuclear pores are important sites of transcription in this species and genome-wide analysis has shown that nuclear-pore-associated proteins bind preferentially to active gene”
Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast (2013, background): “The list of Xrn1-synthegradon genes (responsiveness index >8, this work) was crossed with the genes bound by Mlp1 (Casolari et al., 2004) and with mRNAs bound by Yra1 (Hieronymus and Silver, 2003).”
Insulators: exploiting transcriptional and epigenetic mechanisms (2006, result): “The data, however, are consistent with the possibility that the weak barrier activities of the elements that were investigated in these studies result from a combination of nucleosome exclusion and targeting of the reporter to a subnuclear compartmen”
Characterization of the Drosophila melanogaster genome at the nuclear lamina (2006, background): “A recent genome-wide study in yeast identified predominantly active genes associated with nuclear pore complexes (NPCs”
Beyond the sequence: cellular organization of genome function. (2007, positive): “…however, does not function exclusively as a repressive environment given that a large number of S. cerevisiae genes are repositioned to the periphery where they interact with nuclear-pore components when they become activated (Brickner and Walter, 2004; Casolari et al., 2004; Cabal et al., 2006).”