Insulators: exploiting transcriptional and epigenetic mechanisms

By M. Gaszner, G. Felsenfeld. Nature reviews genetics, 2006

690 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f1189eea7bba3ced96d1055091f9db1440586da4

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Citations in the corpus

A Mammalian enhancer trap resource for discovering and manipulating neuronal cell types (2016, background): “Prior work has distin- guished two functional types of insulators: ‘barrier’ insulators, which prevent the spread of DNA methylation and silencing, and ‘blocking’ insulators, which limit promoter-enhancer interactions (Gaszner and Felsenfeld, 2006).”
CTCF: Master Weaver of the Genome (2009, neutral): “As recently pointed out (Gaszner and Felsenfeld, 2006), most of our knowl- 1196 Cell 137, June 26, 2009 ©2009 Elsevier Inc. edge about insulators comes from experiments that rely on transgene constructs.”
The accessible chromatin landscape of the human genome (2012, background): “Approximately 3% (n 5 75,575) of DHSs localize to transcriptional start sites (TSSs) defined by GENCODE10 and 5% (n 5 135,735, including the aforementioned) lie within 2.5 kilobases (kb) of a TSS.”
Ecdysone Control of Developmental Transitions: Lessons from Drosophila Research (2012, neutral): “inter- and intrachromosomal interactions (33).”
Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data (2013, background): “This suggests that at least some CTCF-bound elements may indeed act as boundary elements, as has long been hypothesized 51,61 .”
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes (2017, background): “Among the genomic regulatory elements that direct higher-order chromatin interactions are insulators, which segregate transcriptionally active and inactive chromatin domains in order to maintain stable gene expression patterns (Gaszner and Felsenfeld 2006).”
High-resolution profiling of histone methylations in the human genome. (2007, background): “CTCF is a multi-zinc finger protein that binds the insulators in vertebrates (Gaszner and Felsenfeld, 2006; Kim et al., 2007).”
Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance (2015, positive): “To prevent undesirable interactions with nearby chromatin, we ﬂanked the reporter allele with two copies of the chicken b -globin HS4 insulator element (Chung et al., 1997; Gaszner and Felsenfeld, 2006) on each side.”
A three-dimensional map of the human genome at kilobase resolution reveals principles of chromatin looping (2014, neutral): “A 3DMap of the Human Genome at Kilobase Resolution Reveals”
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. (2008, background): “CTCF, a ubiquitously-expressed 11-zinc finger protein, is a critical transcription factor, which is involved in transcriptional activation and repression in addition to binding the chromatin insulators (Ohlsson et al. 2001; Gaszner and Felsenfeld 2006; Williams and Flavell 2008).”