Apoptotic and autophagic cell death induced by histone deacetylase inhibitors

By Yufang Shao, Zhonghua Gao, PA Marks, Xuejun Jiang. Proceedings of the National Academy of Sciences of the United States of America, 2004

605 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f94110c2113bcb5e96fd0ee4518c2144f5f24e6c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. D. Tang
2. R. Kang
3. H. J. Zeh
4. Michael Lotze
5. D. Hong
6. M. Bianchi
7. F. Janku
8. PA Marks

In Molecular Biology

1. D. Tang
2. R. Kang
3. PA Marks
4. Michael Lotze
5. H. J. Zeh
6. Kevin J. Tracey
7. Weisheng Xu
8. R. Parmigiani

Citations in the corpus

• The Role of Autophagy in Cancer: Therapeutic Implications (2011, background): “Colorectal cancer In vitro, in vivo CQ þ bortezomib (63) CQ þ vorinostat (56) Phase II HCQ þ XELOX þ bevacizumab Gastrointestinal stromal tumor In vitro, in vivo CQ þ imatinib (75) Prostate cancer In vitro, in vivo CQ þ Src kinase inhibitors (57) Vulvar cancer In vitro CQ þ cetuximab (34) Chronic my”
• Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer (2006, background): “Nevertheless, HDACi can induce cell death with morphological features of autophagy in the absence of activated caspases, indicating that HDACi might work in cells with apoptotic defect”
• The role of autophagy in cancer development and response to therapy (2005, background): “The histone deacetylase inhibitors sodium butyrate and suberoylanilide hydroxamic acid (SAHA) induce apoptosis in parental HeLa cervical cancer cells, but induce autophagic cell death in HeLa cells that overexpress the anti-apoptotic protein BCL-X L”
• Discovery and development of SAHA as an anticancer agent (2007, background): “Trx), which modulate the accumulation of reactive oxygen species (ROS) facilitated cell death (Johnstone and Licht, 2003; Rosato et al., 2003a; Shao et al., 2004; Bhalla, 2005; Dokmanovic and Marks, 2005; Minucci and Pelicci, 2006; Yoo and Jones, 2006).”
• Endogenous HMGB1 regulates autophagy (2010, methodology): “891HMGB1 regulates autophagy • Tang et al. Transmission electron microscopy assessment of autophagosome and autophagolysosomes was performed as previously described (Shao et al., 2004).”
• Autophagy as a target for anticancer therapy (2011, background): “HDAC inhibitors Vorinostat and sodium butyrate increased cell death via autophagy in HeLa cells derived from cervical cancer and chondrosarcoma”
• Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug (2007, background): “Although the mechanisms of SAHA activity are not completely understood, it is clear that SAHA induces cell death of transformed cells by selectively altering gene expression and the function of proteins that cause caspase-dependent and caspase-independent cell deat”
• Histone deacetylase inhibitors: molecular mechanisms of action (2007, methodology): “HDACi induces autophagic cell death and senescence HeLa cells with Apaf-1 knockout or Bcl-XL overexpression were induced to autophagic cell death with autophagic vacuoles in the cytoplasm, when cultured with vorinostat or butyrate (Shao et al., 2004).”