Discovery and development of SAHA as an anticancer agent

By PA Marks. Oncogene, 2007

602 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/af20799279f6cdec773414ac6ccee2508c850da5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Rusty L. Montgomery
2. M. Haberland
3. Guangdi Wang
4. E. Olson
5. Tien L. Huang
6. Madhusoodanan Mottamal
7. Shilong Zheng
8. Deepak Srivastava

Citations in the corpus

• Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents (2015, background): “In terms of its target, vorinostat inhibits Class I, II and IV HDAC proteins, but not the NAD+-dependent Class III HDAC [45–47].”
• The many roles of histone deacetylases in development and physiology: implications for disease and therapy (2009, background): “The exact mechanism for the effect of HDAC inhibitors on tumour cells is currently unknown, and numerous explanations, such as changes in gene transcription, direct induction of apoptosis, production of reactive oxygen species and induction of cell-cycle arrest, have been propose”