MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

By Shuomin Zhu, Hailong Wu, Fangting Wu, D. Nie, S. Sheng, Yin-yuan Mo. Cell Research, 2008

1,179 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f8f7fdc6477d292ad774d62a8d73c096c554d564

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Citations in the corpus

Integrated Genomic Characterization of Papillary Thyroid Carcinoma (2014, background): “PDCD4 is a miR-21 target gene reported to function as a tumor suppressor in diverse tumors (Zhu et al., 2008).”
Integrating mechanisms of pulmonary fibrosis (2011, background): “4), suggesting it can function as an oncogene (Meng et al., 2007; Zhu et al., 2007, 2008; Asangani et al., 2008). miR-21 also operates as antiapoptotic factor in tumor cells (Chan et al., 2005).”
miR-21: a small multi-faceted RNA (2008, background): “[53, 60], colorectal cancer [52] and glioma [49], as well as in a murine JB6 epidermal model of neoplastic transformation [50].”
MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008, background): “Our analysis also confirmed tropomyosin 1 (TPM1) regulation by miR-21, previously reported to occur in MCF7 cells (59, 60).”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “Similarly, repression of PDCD4 and mapsin are thought to promote cancer progression by promoting cell invasion and metastasis [277, 280, 281, 289].”
MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. (2008, background): “The results suggest that, as an oncogenic miRNA, miR-21 has a role not only in tumor growth but also in invasion and tumor metastasis by targeting multiple tumor/metastasis suppressor genes (Zhu et al. 2008).”
Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin (2008, background): “Recent findings have confirmed a critical role of miRNA as powerful diagnostic and prognostic indicators of human breast cancer (15, 16, 37, 38, 44), resulting in the develop-”
The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform. (2009, background): “It has been shown to modulate expression of PTEN in hepatocellular carcinoma [10] as well as PDCD4 and maspin, two genes involved in regulating invasion and metastasis [21,22].”
Lost in translation: an assessment and perspective for computational microRNA target identification (2009, background): “Each miRNA is 19–24 nucleotides in length and is processed from a longer transcript, referred to as the primary transcript (pri-miRNA), which can be up to thousands of nucleotides long.”
Modulation of K-ras-dependent lung tumorigenesis by microRNA-21 (2010, positive): “Knockdown of miR-21 in the metastatic breast cancer MD-MBA-231 cells reduced invasion and metas- tasis (Zhu et al., 2008).”
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (2012, neutral): “…stimulates invasation, extravasation and metastasis in different tumour types, included colorectal cancer (Asangani et al, 2008) and breast cancer (Zhu et al, 2008), while oncosuppressor miR-205 has opposite effects, reducing invasion in vitro and suppressing lung metastasis in vivo (Wu et al,…”