Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation
By G. den Besten, A. Bleeker, A. Gerding, K. van Eunen, R. Havinga, T. V. van Dijk, M. Oosterveer, J. Jonker, Albert K. Groen, D. Reijngoud and 1 more. Diabetes, 2015
1,016 citations recorded by the source corpus.
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/709a79725a30b02e3818835d35b75f1eff0ea518
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In Molecular Biology
- Lucy J. Mailing
- D. Ríos-Covian
- G. Svegliati-Baroni
- P. Ruas-Madiedo
- C. G. de los Reyes-Gavilán
- T. Preston
- N. Salazar
- W. Tang
In Physiology
Citations in the corpus
- Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans (2017, background): “SCFA are also energy substrates for numerous tissue types, including colon (35), adipose (36), and muscle (32), indi-”
- Lipotoxicity and the gut-liver axis in NASH pathogenesis. (2018, background): “The two best studied incretins, GIP and GLP-1, exert their insulinotropic actions through distinct G-proteincoupled receptors highly expressed on islet beta-cells The GLP-1 receptors (GLP-1R) are also widely expressed in non-islet cells such as kidney, intestinal smooth muscle, brain, adipose tissue”
- Gut Microbiota in Cardiovascular Health and Disease (2017, background): “In addition, bacterial fermentation of prebiotic soluble fiber generates SCFA, which is thought to exert several beneficial effects including potential amelioration of CVD risk factors.(12,161,162) Given that an alteration in gut microbiota composition has been linked to different diseases, modulati”
- Short chain fatty acids in human gut and metabolic health. (2020, neutral): “Five studies have reported the effects of incorporating SCFA into the diet of rodents (Table 3, rodents), with four observing no effects on energy intake (De Vadder et al. , 2014; Den Besten et al. , 2015; Gao et al. , 2009; Henagan et al. , 2015).”
- Butyrate: A Double-Edged Sword for Health? (2018, methodology): “Another study in mice also showed that dietary butyrate supplementation prevented and reversed high-fat-diet–induced obesity by downregulating the expression and activity of PPAR-γ , promoting a change from lipogenesis to lipid oxidation (88).”
- Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health (2016, background): “…been proposed to explain these effects, the activation of signaling pathways mediated by protein kinases, such as AMP-activated protein kinase (Gao et al., 2009; Peng et al., 2009; Den Besten et al., 2015) or mitogen-activated protein kinases (MAPK; Jung et al., 2015), being a common observation.”
- Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism (2016, background): “Acetate, propionate and butyrate appear to regulate hepatic lipid and glucose homeostasis in an adenosine monophosphate-activated protein kinase dependent manner involving peroxisome proliferatoractivated receptor-g regulated effects on gluconeogenesis and lipogenesis.(44) Recently, evidence has als”