A single autophosphorylation site on KDR/Flk‐1 is essential for VEGF‐A‐dependent activation of PLC‐γ and DNA synthesis in vascular endothelial cells

By Tomoko Takahashi, S. Yamaguchi, K. Chida, M. Shibuya. EMBO Journal, 2001

789 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f89a356aed2eccadd9aa1b28d605a2ffc0e47791

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Shibuya
2. R. Roskoski
3. E. Dejana
4. T. Balla

In Immunology and Allergy

1. L. Claesson‐Welsh
2. E. Dejana
3. T. Balla
4. M. Shibuya
5. R. Roskoski
6. S. Koch

In Molecular Biology

1. L. Claesson‐Welsh
2. M. Shibuya
3. R. Roskoski
4. A. V. van Oosterom
5. E. Dejana
6. T. Balla
7. A. Hoeben
8. E. D. de Bruijn

Citations in the corpus

• Endothelial cell–cell junctions: happy together (2004, background): “For instance, specific tyrosines are required for the binding and activation of phospholipase Cγ (PLCγ), which would then trigger proliferatio”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “These phenotypes suggest that the effects of VEGF on vascular endothelium are mediated mostly by PLC mediated pathways (1035, 1301, 1516).”
• Vascular endothelial growth factor (VEGF) signaling in tumor progression. (2007, background): “23 (MSS31) cells, which are derived from endothelial cells, with adenovirus vectors expressing wild type and various VEGFR2 mutants [127].”
• Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. (2011, background): “An SH2 domain of PLCγ specifically binds to the 1175-PY site of VEGFR-2 (1173-PY in mice) and further activates PKC, particularly the PKCβ pathway.(27,28) An 1175-phenylalanine (F) mutant of VEGFR-2 significantly decreases the MAPK pathway under stimulation with VEGF and cannot efficiently activate ”
• Vascular Endothelial Growth Factor and Angiogenesis (2004, background): “Autophosphorylation of Tyr951 creates a binding site for the VEGFR-associated protein (Wu et al., 2000) and Tyr1175 creates a binding site for Sck (Warner et al., 2000) and PLC 1 (Takahashi et al., 2001).”
• Signal transduction by vascular endothelial growth factor receptors. (2012, background): “2) (Takahashi et al. 2001; Matsumoto et al. 2005).”