Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis

By H. Nozawa, C. Chiu, D. Hanahan. Proceedings of the National Academy of Sciences of the United States of America, 2006

923 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f83991cda6ff659f8d0473a576cc78183b0ae296

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Citations in the corpus

Tumor associated macrophages and neutrophils in cancer. (2013, background): “For instance, eutrophil-derived MMP-9 has been involved in the angiogenic witch through the release of VEGF from the ECM and neutrophils ere identified as the major source of MMP-9 in human head and eck cancer and hepatocellular carcinoma (Dumitru et al. 2012; uang et al. 2011; Nozawa et al. 2006).”
Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “Studies have indicated a variety of molecules and mechanisms involved with the generation of the PMN, such as tumour-derived secreted factors (TDSFs) and tumour-derived extracellular vesicles (EVs) [218,219].”
Coordinated regulation of myeloid cells by tumours (2012, background): “It is likely that granulocytes facilitate the angiogenic switch by expressing MMP9, which promotes tumour angiogenesis by inducing VEGF expression in neoplastic tissu”
Polarization of Tumor-Associated Neutrophil (TAN) Phenotype by TGF-β: “N1” versus “N2” TAN (2009, result): “This explanation is consistent with at least two other earlier studies (Nozawa et al., 2006; Pekarek et al., 1995) and with our data showing that depleting neutrophils slowed tumor growth, even in the absence of CD8 + cells (Figures 3 and 6).”
Chemotaxis in cancer (2011, background): “, which drive VEGF activation through MMP9 secretio”
Tumor-associated neutrophils: friend or foe? (2012, positive): “these “pro-tumorigenic” N2 neutrophils, therefore, inhibits tumor growth [6,67,70]”
Tumors as organs: complex tissues that interface with the entire organism (2010, positive): “In contrast, N2 neutrophils promote cancer by producing angiogenic factors and ECM-degrading enzymes (Nozawa et al., 2006; Shojaei et al., 2008) and by suppressing the antitumor immune response (Schmielau and Finn, 2001).”
The polarization of immune cells in the tumour environment by TGFβ (2010, background): “N2 neutrophils are characterized by an expression profile that promotes tumour angiogenesis and metastasi”
Accessories to the crime: functions of cells recruited to the tumor microenvironment. (2012, positive): “…include neutrophils and their myeloid progenitors, which produce MMP-9 and are demonstrably involved in angiogenic switching in some tumors (Nozawa et al., 2006; Pahler et al., 2008; Shojaei et al., 2007 ), and platelets, the enucleated minicells spun off from megakeryocytes whose…”
Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting. (2010, positive): “Both xenogeneic and syngeneic animal models can be used; syngeneic model is preferred as it ensures natural tumor vessels development accounting for role of immunomodulators secreted by infiltrating neutrophils and macrophages on the tumor vasculature (22, 23).”
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, background): “, 2001), and depleting neutrophils in a mouse model of pancreatic cancer markedly reduces angiogenic switching in dysplasias (Nozawa et al., 2006).”
Eicosanoids and cancer (2010, background): “; neutrophil infiltration has also been shown to be essential for angiogenesis in other tumour model”